Kikuchi Shogo, Obata Yuki, Sasakabe Tae, Kawai Sayo, Wang Chaochen, Lin Yingsong
Department of Public Health Aichi Medical University School of Medicine Nagakute Aichi Japan.
Present address: College of Pharmacy Kinjo Gakuin University Nagoya Aichi Japan.
JGH Open. 2022 Feb 22;6(3):166-170. doi: 10.1002/jgh3.12714. eCollection 2022 Mar.
The causal relationship between () infection and gastric cancer has been established. Although the magnitude of the carcinogenic effect of is the next concern, it has not been sufficiently evaluated in Japan. Spontaneous disappearance of infection may have provoked underestimation of the carcinogenic effect of the infection. To reduce the influence, a comparison should be carried out between subjects with and without the infection history. Cutoff values of antibody lower than the manufacturer's recommendation are known to be more appropriate to diagnose history of infection. The aim was to evaluate the carcinogenic effect of .
A case-control study consisting of 275 gastric cancer patients and 275 age- and sex-matched controls was performed. Serum antibody was measured using the "JHM-Cap" kit with a domestic antigen (cut value of the manufacturer's recommendation was 2.3 EV: ELISA value). Using a conditional logistic model, the odds ratios (ORs) for five cutoff values adjusted for smoking and drinking doses were calculated.
For cutoff values of 1.25, 1.5, 1.75, 2.0, and 2.3 EV, the ORs (95% confidence intervals) were 67.7 (9.1, 502), 37.2 (8.8, 157), 21.3 (9.0, 60.2), 25.5 (9.0, 72.7), and 25.9 (9.2, 73.2), respectively.
These results suggest that the risk ratio of gastric cancer between subjects with and without history of infection in Japan may exceed 20.
（）感染与胃癌之间的因果关系已经确立。尽管（）致癌作用的程度是接下来需要关注的问题，但在日本尚未得到充分评估。（）感染的自然消失可能导致对该感染致癌作用的低估。为减少这种影响，应在有和没有感染史的受试者之间进行比较。已知低于制造商推荐值的（）抗体临界值更适合诊断（）感染史。目的是评估（）的致癌作用。
进行了一项病例对照研究，包括275例胃癌患者和275例年龄及性别匹配的对照。使用含有国产抗原的“JHM-Cap”试剂盒检测血清（）抗体（制造商推荐的临界值为2.3 EV：ELISA值）。使用条件逻辑模型，计算调整吸烟和饮酒量后的五个临界值的比值比（OR）。
对于1.25、1.5、1.75、2.0和2.3 EV的临界值，OR（95%置信区间）分别为67.7（9.1，502）、37.2（8.8，157）、21.3（9.0，60.2）、25.5（9.0，72.7）和25.9（9.2，73.2）。
这些结果表明，在日本，有和没有（）感染史的受试者之间胃癌的风险比可能超过20。
