Mitra Subarna, Saharia Gautom K, Jena Saubhagya K
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Department of Biochemistry, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Indian J Endocrinol Metab. 2021 Nov-Dec;25(6):545-550. doi: 10.4103/ijem.ijem_421_21. Epub 2022 Feb 17.
Polycystic ovary syndrome (PCOS) has a predilection for several cardio-metabolic disorders in future. Levels of anti-Mullerian hormone (AMH), a marker of ovarian ageing, are higher in women with PCOS women than in controls. However, whether and how AMH concentrations influence the cardio-metabolic risk in PCOS is yet to be established.
This study was done to determine the correlation between AMH levels and various cardiometabolic parameters in women with PCOS and to compare AMH levels in PCOS with and without metabolic syndrome (MS).
In total, 144 women aged 20-40 years and diagnosed as PCOS by the Rotterdam criteria were included in this cross-sectional study. Their anthropometry and blood pressure were recorded. Fasting lipid profile, fasting glucose, fasting insulin, homeostasis model assessment-insulin resistance, total testosterone, and AMH were estimated. The correlation between AMH and cardiometabolic parameters was determined.
Serum AMH levels had no correlation with any component of MS. The AMH values were comparable between those with and without MS despite differences in the metabolic profile (11.39 ± 5.31 vs 11.56 ± 5.64 ng/mL, = 0.861).
AMH levels do not correlate with components of MS so it may not be useful as an indicator of cardiovascular risk, insulin resistance, or MS in PCOS.
多囊卵巢综合征（PCOS）患者未来易患多种心血管代谢紊乱疾病。抗苗勒管激素（AMH）是卵巢衰老的标志物，PCOS女性体内的AMH水平高于对照组。然而，AMH浓度是否以及如何影响PCOS患者的心血管代谢风险尚待确定。
本研究旨在确定PCOS女性AMH水平与各种心血管代谢参数之间的相关性，并比较有和没有代谢综合征（MS）的PCOS患者的AMH水平。
本横断面研究共纳入144名年龄在20 - 40岁之间、根据鹿特丹标准诊断为PCOS的女性。记录她们的人体测量数据和血压。测定空腹血脂谱、空腹血糖、空腹胰岛素、稳态模型评估胰岛素抵抗、总睾酮和AMH。确定AMH与心血管代谢参数之间的相关性。
血清AMH水平与MS的任何组分均无相关性。尽管代谢谱存在差异，但有和没有MS的患者的AMH值相当（11.39±5.31 vs 11.56±5.64 ng/mL，P = 0.861）。
AMH水平与MS的组分不相关，因此它可能无法作为PCOS患者心血管风险、胰岛素抵抗或MS的指标。
