Shahbazi Marjan, Khazaei Salman, Moslehi Samad, Shahbazi Fatemeh
Department of Occupational Therapy, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
Int J Pediatr. 2022 Mar 20;2022:9161074. doi: 10.1155/2022/9161074. eCollection 2022.
The effectiveness of massage therapy in the treatment of neonatal jaundice has been established in previous literature, but how much the level of massage can reduce the mean of bilirubin in neonates with jaundice is a question that has been addressed in this review.
Four electronic databases, including Cochrane, PubMed, Scopus, and Web of Science, were searched for relevant literature. For the dose-response association between massage therapy and treatment of neonatal icterus, we conducted a meta-analysis using the random-effects model. For any level of intervention, we calculated the overall mean difference (MD) with 95% confidence intervals (CI).
Twenty studies were included in our meta-analysis. There was a positive and significant increasing dose-response trend between massage therapy and the mean reduction of bilirubin in neonates with hyperbilirubinemia as follows: <50 minutes massage during the experiment -0.36 (95% CI: -0.67, -0.06; = 66%), 50-60 minutes massage during the experiment -0.41 (95% CI: -0.95, 0.13; = 84%), and ≥101 minutes massage during the experiment -1.20 (95% CI: -1.63, -0.78; = 83%). The heterogeneity across studies was mild to moderate.
The presence of a dose-response relationship favors the causal relationship between massage therapy and reduction of neonatal jaundice.
既往文献已证实按摩疗法在治疗新生儿黄疸方面的有效性，但按摩程度能在多大程度上降低黄疸新生儿的胆红素均值是本综述所探讨的问题。
检索了四个电子数据库，包括考克兰图书馆、PubMed、Scopus和科学网，以查找相关文献。对于按摩疗法与新生儿黄疸治疗之间的剂量反应关联，我们使用随机效应模型进行了荟萃分析。对于任何干预水平，我们计算了总体平均差（MD）及95%置信区间（CI）。
我们的荟萃分析纳入了20项研究。按摩疗法与高胆红素血症新生儿胆红素均值降低之间存在正向且显著的剂量反应增加趋势，具体如下：实验期间按摩<50分钟时为-0.36（95%CI：-0.67，-0.06；I² = 66%），实验期间按摩50 - 60分钟时为-0.41（95%CI：-0.95，0.13；I² = 84%）以及实验期间按摩≥101分钟时为-1.20（95%CI：-1.63，-0.78；I² = 83%）。各研究间的异质性为轻度至中度。
剂量反应关系的存在支持按摩疗法与新生儿黄疸减轻之间的因果关系。
