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不明原因发热作为念珠菌性椎体骨髓炎的首发表现:一例报告

Fever of unknown origin as the first presentation of candida vertebral osteomyelitis: A case report.

作者信息

Farahzadi Athena, Mahmoodzadeh Habibollah

机构信息

Division of Surgical Oncology Cancer institute Tehran University of Medical Sciences Tehran Iran.

出版信息

Clin Case Rep. 2022 Mar 23;10(3):e05582. doi: 10.1002/ccr3.5582. eCollection 2022 Mar.

Abstract

Candida osteomyelitis is a rare disorder; however, its incidence has drastically risen especially during the last 3 decades. Diagnosis is usually delayed due to nonspecific symptoms. Thus, its management would not be performed at the proper time, which leads to increased morbidity. The optimal management of candida osteomyelitis is not clearly defined but most recommendations advise prolonged antifungal therapy in addition to surgery. Here, we report candida osteomyelitis in a patient with a history of pancreatic adenocarcinoma that presented with prolonged FUO as her first presentation. Fortunately, her symptoms completely resolved after prolonged medical therapy despite delay diagnosis due to her unusual presentation. To the best of our knowledge, it is the first report of candida vertebra osteomyelitis that presents with prolonged FUO as the first presentation.

摘要

念珠菌性骨髓炎是一种罕见的疾病;然而,其发病率在过去30年中急剧上升。由于症状不具特异性,诊断通常会延迟。因此,无法在适当时间进行治疗,导致发病率增加。念珠菌性骨髓炎的最佳治疗方法尚未明确界定,但大多数建议除手术外还建议延长抗真菌治疗时间。在此,我们报告一例有胰腺腺癌病史的患者发生念珠菌性骨髓炎,其首发表现为长期不明原因发热。幸运的是,尽管因其不寻常的表现导致诊断延迟,但经过长时间的药物治疗后,她的症状完全缓解。据我们所知,这是首例以长期不明原因发热为首发表现的念珠菌性椎体骨髓炎报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c73/8943113/d8feb3bc7847/CCR3-10-e05582-g001.jpg

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