Liang Songnian, Huang Kun
Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Department of Ultrasonic Diagnosis, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
J Oncol. 2022 Mar 21;2022:5916379. doi: 10.1155/2022/5916379. eCollection 2022.
The study was conducted to investigate the correlation between the ultrasonographic appearance of a thyroid nodule and the BRAF V600E mutation. Patients with thyroid nodules ( = 186), for which BRAF V600E testing and cytopathology analysis were performed, and who underwent subsequent surgery for nodule resection were enrolled in this study. For each patient, color Doppler ultrasonography was performed to observe the variables of the nodules. The nodules were then characterized using the thyroid imaging reporting and data system classification TI-RADS. Furthermore, the ultrasonographic appearance of the control group, encompassing patients with nodular thyroid goiters, and the case group, encompassing patients with papillary thyroid microcarcinoma (PTMC), was statically analyzed. Similarly, a statistical analysis of the ultrasonographic appearance of the BRAF V600E-positive and BRAF V600E-negative subgroups was also performed. The accuracy was significantly different for the corresponding values when color Doppler ultrasonography, BRAF V600E testing, or cytopathology alone was used for diagnosis. There were significant differences in the ultrasonographic appearance variables between the control and case groups. Comparing with the BRAF V600E-negative subgroup of the case group, the ultrasonographic appearances of the BRAF V600E-positive subgroup showed less circumscribed and more irregularly shaped nodules, with significantly different aspect ratios of >1. The combination of BRAF V600E testing and color Doppler ultrasonography or cytopathology improved the accuracy of the PTMC diagnose. We found that the ultrasonographic appearance of thyroid nodules was related to PTMC.
本研究旨在探讨甲状腺结节的超声表现与BRAF V600E突变之间的相关性。纳入了186例接受BRAF V600E检测和细胞病理学分析并随后接受结节切除手术的甲状腺结节患者。对每位患者进行彩色多普勒超声检查以观察结节的各项变量。然后使用甲状腺影像报告和数据系统分类（TI-RADS）对结节进行特征描述。此外，对包括结节性甲状腺肿患者的对照组和包括甲状腺微小乳头状癌（PTMC）患者的病例组的超声表现进行了统计学分析。同样，也对BRAF V600E阳性和BRAF V600E阴性亚组的超声表现进行了统计学分析。当单独使用彩色多普勒超声、BRAF V600E检测或细胞病理学进行诊断时，相应值的准确性存在显著差异。对照组和病例组之间的超声表现变量存在显著差异。与病例组的BRAF V600E阴性亚组相比，BRAF V600E阳性亚组的超声表现显示结节边界欠清晰且形状更不规则，纵横比>1有显著差异。BRAF V600E检测与彩色多普勒超声或细胞病理学相结合提高了PTMC诊断的准确性。我们发现甲状腺结节的超声表现与PTMC有关。
