Centre for Medicines Information and Pharmaceutical Care (CMIPC), Faculty of Pharmacy, Universitas Surabaya, Surabaya, East Java, Indonesia.
Faculty of Pharmacy, Universitas Surabaya, Surabaya, East Java, Indonesia.
PeerJ. 2022 Mar 25;10:e13171. doi: 10.7717/peerj.13171. eCollection 2022.
Hypertension is a major risk factor for global disease burden, however, little is known regarding the profiles of patients with hypertension in Indonesian primary care settings.
This study aimed to profile medication use, adherence to medications and lifestyle modifications as well as blood pressure control among patients with hypertension in Indonesian primary health centres (PHCs).
A cross-sectional study design used a structured data collection tool (questionnaire and checklist). Patients aged ≥18 years with a diagnosis of hypertension, and prescribed an antihypertensive medication, and attending follow-up visits in the five PHCs in Surabaya, Indonesia, during a two-week study period (May-October 2019) were included. Descriptive analyses summarised the data, while binary logistic regression provided any independent associations between adherence profiles and blood pressure control.
Of 457 eligible patients, 276 patients consented: PHC A ( = 50/91), PHC B ( = 65/116), PHC C ( = 47/61), PHC D ( = 60/88), PHC E ( = 54/101), giving an overall response rate of 60.4%. Patients were mainly treated with a single antihypertensive medication, , amlodipine (89.1%), and many had not achieved blood pressure targets (68.1%). A majority reported notable levels of non-adherence to medication (low/intermediate, 65.2%) and poor healthy lifestyle behaviours, particularly physical activity (inadequate, 87.7%) and discretionary salt use (regularly, 50.4%). Significant associations were found between low medication adherence, discretionary salt use and smoking, with blood pressure control.
The study findings provide the evidence needed to improve the current level of sub-optimal blood pressure management among patients with hypertension in these Indonesian primary care settings. Particular emphasis should be placed on antihypertensive medication adherence and healthy lifestyle behaviours through locally tailored hypertension-related interventions.
高血压是全球疾病负担的一个主要危险因素,然而,人们对印度尼西亚基层医疗保健环境中高血压患者的情况知之甚少。
本研究旨在描述印度尼西亚基层医疗保健中心(PHC)高血压患者的药物使用、药物依从性和生活方式改变以及血压控制情况。
采用横断面研究设计,使用结构化数据收集工具(问卷和检查表)。在 2019 年 5 月至 10 月为期两周的研究期间,纳入在印度尼西亚泗水的五家 PHC 就诊、年龄≥18 岁、诊断为高血压并开具降压药物且正在接受随访的患者。描述性分析总结了数据,而二元逻辑回归则提供了药物依从性和血压控制之间的任何独立关联。
在 457 名符合条件的患者中,有 276 名患者同意参与:PHC A(50/91),PHC B(65/116),PHC C(47/61),PHC D(60/88),PHC E(54/101),总体应答率为 60.4%。患者主要接受单一降压药物治疗,氨氯地平(89.1%),许多患者未达到血压目标(68.1%)。大多数患者报告药物依从性低(中低水平,65.2%)和不良的健康生活方式行为,尤其是体力活动(不足,87.7%)和随意用盐(经常,50.4%)。药物依从性低、随意用盐和吸烟与血压控制显著相关。
研究结果为改善这些印度尼西亚基层医疗保健环境中高血压患者目前不理想的血压管理水平提供了证据。应特别强调通过针对当地情况的高血压相关干预措施,提高降压药物的依从性和健康的生活方式行为。