Prusoff W H, Lin T S, Zucker M
Antiviral Res. 1986 Oct;6(6):311-28. doi: 10.1016/0166-3542(86)90014-8.
Serendipity and random screening have been successful in producing effective antiviral agents. The increase in our knowledge of the basic biochemistry of viral replication and of virus-host interrelationships has revealed not only an understanding of the targets upon which existing antiviral agents exert their inhibitory effect, but also has uncovered new potential targets. The hope is that such molecular understanding will afford the synthesis of compounds with selective antiviral activity. A review of various viral targets which are potentially susceptible to attack, and a few approaches for development of antiviral agents are presented.
偶然发现和随机筛选在生产有效的抗病毒药物方面已取得成功。我们对病毒复制的基础生物化学以及病毒与宿主相互关系的了解不断增加，这不仅揭示了现有抗病毒药物发挥抑制作用的靶点，还发现了新的潜在靶点。希望这种分子层面的理解将有助于合成具有选择性抗病毒活性的化合物。本文综述了各种可能易受攻击的病毒靶点，以及抗病毒药物开发的一些方法。
