Protein engineering and site-directed mutagenesis. Patents and literature.
作者信息
Linhardt R J
出版信息
Appl Biochem Biotechnol. 1986 Aug;13(1):75-83. doi: 10.1007/BF02798438.
PMID:3535672
Abstract
摘要
相似文献
1
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本文引用的文献
1
Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding.通过定点诱变重新设计酶结构：酪氨酰tRNA合成酶与ATP结合
Nature. 1982 Oct 21;299(5885):756-8. doi: 10.1038/299756a0.
2
Genetic dissection of tyrosyl-tRNA synthetase.酪氨酰 - tRNA合成酶的遗传学剖析
Biochem Soc Trans. 1984 Apr;12(2):224-5. doi: 10.1042/bst0120224.
3
A large increase in enzyme-substrate affinity by protein engineering.通过蛋白质工程实现酶 - 底物亲和力的大幅提高。
Nature. 1984;307(5947):187-8. doi: 10.1038/307187a0.
4
Site-directed mutagenesis as a probe of enzyme structure and catalysis: tyrosyl-tRNA synthetase cysteine-35 to glycine-35 mutation.定点诱变作为酶结构与催化作用的探针：酪氨酰-tRNA合成酶半胱氨酸-35突变为甘氨酸-35
Biochemistry. 1983 Jul 19;22(15):3581-6. doi: 10.1021/bi00284a007.
5
Directed mutagenesis as a technique to study protein function: application to beta-lactamase.定向诱变作为研究蛋白质功能的技术：在β-内酰胺酶中的应用
Biochem Soc Trans. 1984 Apr;12(2):226-8. doi: 10.1042/bst0120226.
6
Need a catalyst? Design an enzyme.
Science. 1984 Jan 20;223(4633):269-71. doi: 10.1126/science.6608147.
7
Genetic engineering and pharmaceuticals.基因工程与制药
Nature. 1984;312(5992):303-5. doi: 10.1038/312303a0.
8
Structural intermediates of deletion mutagenesis: a role for palindromic DNA.缺失诱变的结构中间体：回文DNA的作用
Proc Natl Acad Sci U S A. 1984 Jan;81(2):512-6. doi: 10.1073/pnas.81.2.512.
9
The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus).利用双突变体检测嗜热栖热放线菌酪氨酰-tRNA合成酶活性位点的结构变化。
Cell. 1984 Oct;38(3):835-40. doi: 10.1016/0092-8674(84)90278-2.
10
Site-specific mutagenesis of the human interleukin-2 gene: structure-function analysis of the cysteine residues.人白细胞介素-2基因的位点特异性诱变：半胱氨酸残基的结构-功能分析
Science. 1984 Jun 29;224(4656):1431-3. doi: 10.1126/science.6427925.
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