Huang Jinke, Zhang Jiaqi, Wang Yifan, Ma Jing, Yang Xuefei, Guo Xiaoxue, Lv Mi, Ma Jinxin, Zheng Yijun, Wang Fengyun, Tang Xudong
Department of Gastroenterology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China.
China Academy of Chinese Medical Sciences, Beijing, China.
Gastroenterol Res Pract. 2022 Mar 14;2022:7942845. doi: 10.1155/2022/7942845. eCollection 2022.
Gegen Qinlian decoction (GQD), a Chinese herbal compound, has been widely used in the treatment of ulcerative colitis (UC) in China. However, evidence from systematic reviews (SRs)/meta-analyses (MAs) of GQD in UC remains highly controversial. To collate, evaluate, and synthesize the current evidence, we carried out this study.
SRs/MAs of GQD for UC were obtained from eight databases. Methodological Quality of Systematic Reviews 2 (AMSTAR-2) was utilized to appraise the methodological quality, Preferred Reporting Item for Systematic Reviews and Meta-Analyses (PRISMA) for reporting quality, and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) for evidence quality.
Four eligible SRs/MAs were obtained. According to AMSTAR 2, all SRs/MAs were graded as critically low quality. According to PRISMA checklist, all SRs/MAs failed to report the information of protocol and registration. With GRADE, no outcome measure with high-quality evidence was found, and the evidence quality for outcome measures was in the moderate to critically low levels.
GQD with conventional medicine (CM) seems to be more effective in UC than CM alone. This finding provides a new alternative strategy for the treatment of UC. However, owing to the limitations of the evidence provided by the included SRs/MAs, this conclusion must be treated with caution.
葛根芩连汤（GQD）是一种中药复方，在中国已被广泛用于治疗溃疡性结肠炎（UC）。然而，关于GQD治疗UC的系统评价（SRs）/Meta分析（MAs）的证据仍存在高度争议。为了整理、评估和综合当前证据，我们开展了本研究。
从八个数据库中获取关于GQD治疗UC的SRs/MAs。采用系统评价方法学质量2（AMSTAR-2）评估方法学质量，采用系统评价和Meta分析优先报告条目（PRISMA）评估报告质量，采用推荐分级的评估、制定与评价（GRADE）评估证据质量。
获得四项合格的SRs/MAs。根据AMSTAR 2，所有SRs/MAs的质量等级均为极低质量。根据PRISMA清单，所有SRs/MAs均未报告方案和注册信息。采用GRADE方法，未发现高质量证据的结局指标，结局指标的证据质量为中度至极低水平。
GQD联合传统医学（CM）治疗UC似乎比单纯使用CM更有效。这一发现为UC的治疗提供了一种新的替代策略。然而，由于纳入的SRs/MAs所提供证据的局限性，这一结论必须谨慎对待。
