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接种 BNT162b2 加强针后对 SARS-CoV-2 奥密克戎 BA.1 和 BA.2 的血清中和作用。

Serum Neutralization of SARS-CoV-2 Omicron BA.1 and BA.2 after BNT162b2 Booster Vaccination.

出版信息

Emerg Infect Dis. 2022 Jun;28(6):1274-1275. doi: 10.3201/eid2806.220503. Epub 2022 Mar 31.

DOI:10.3201/eid2806.220503
PMID:35356875
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9155893/
Abstract

The SARS-CoV-2 Omicron variant BA.2 sublineage is rapidly replacing earlier Omicron lineages, suggesting BA.2 has increased vaccine evasion properties. We measured neutralization titers of authentic BA.1 and BA.2 isolates in serum samples from persons who received the BNT162b2 booster vaccine. All samples neutralized BA.1 and BA.2 at equal median values.

摘要

奥密克戎变异株 BA.2 亚系正在迅速取代早期的奥密克戎谱系，表明 BA.2 具有更高的疫苗逃逸能力。我们测量了接受 BNT162b2 加强针疫苗接种者血清样本中真实的 BA.1 和 BA.2 分离株的中和滴度。所有样本对 BA.1 和 BA.2 的中和能力均处于中位数水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c01/9155893/2b8294a3297f/22-0503-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c01/9155893/2b8294a3297f/22-0503-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c01/9155893/2b8294a3297f/22-0503-F.jpg

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[1]
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Virol J. 2023-11-15

[2]
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Emerg Infect Dis. 2022-12

[3]
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[4]
Serum neutralization of SARS coronavirus 2 Omicron sublineages BA.1 and BA.2 and cellular immune responses 3 months after booster vaccination.

Clin Microbiol Infect. 2023-2

[5]
Neutralization of SARS-CoV-2 Omicron and Delta Variants in Relation to Vaccine-Induced Antibody Levels in Kidney Transplant Recipients and Healthy Controls.

Microbiol Spectr. 2022-10-26

[6]
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Front Immunol. 2022

[7]
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Br J Biomed Sci. 2022

[8]
Antibody Response against Circulating Omicron Variants 8 Months after the Third Dose of mRNA Vaccine.

Vaccines (Basel). 2022-9-10

[9]
Immunogenicity and safety of BNT162b2 mRNA vaccine in Chinese adults: A phase 2 randomised clinical trial.

Lancet Reg Health West Pac. 2022-12

[10]
COVID-19 Vaccine Booster Strategies for Omicron SARS-CoV-2 Variant: Effectiveness and Future Prospects.

Vaccines (Basel). 2022-7-30

本文引用的文献

[1]
Neutralization of the SARS-CoV-2 Omicron BA.1 and BA.2 Variants.

N Engl J Med. 2022-4-21

[2]
Covid-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant.

N Engl J Med. 2022-4-21

[3]
The SARS-CoV-2-neutralizing capacity of kidney transplant recipients 4 weeks after receiving a second dose of the BNT162b2 vaccine.

Kidney Int. 2021-11

[4]
Assignment of epidemiological lineages in an emerging pandemic using the pangolin tool.

Virus Evol. 2021-7-30

[5]
Nextstrain: real-time tracking of pathogen evolution.

Bioinformatics. 2018-12-1

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