Department of Chest Diseases, Acıbadem Mehmet Ali Aydınlar University Faculty of Medicine, Maslak Hospital, Istanbul, Turkey,Department of Biochemistry, Sisli Hamidiye Etfal Education and Research Hospital, Istanbul, Turkey,Department of Biochemistry, Faculty of Medicine, Halic University, Istanbul, Turkey,Department of Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey,Department of Nuclear Medicine, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey,Department of Physiology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey,Department of Medical Biochemistry, Faculty of Medicine, Istanbul Atlas University, Istanbul, Turkey.
Medicine (Baltimore). 2022 Mar 18;101(11). doi: 10.1097/MD.0000000000028949.
Our aim in this study was to evaluate the prognostic significance of sialic acid (SA) and prolidase activity and to evaluate the association between airflow obstruction severity and these parameters in chronic obstructive pulmonary disease (COPD) patients.Ninety-four patients (84 M, 10 F) and 34 healthy subjects (19 M, 15 F) were included into the study. COPD staging was performed to COPD patients according to new global initiative for chronic obstructive lung disease criteria which includes pulmonary function tests, symptoms and hospitalization; COPD patients were divided into 4 subgroups as group A (n = 25), group B (n = 19), group C (n = 20), and group D (n = 28).SA and C-reactive protein levels were significantly higher than the control group in all COPD groups. SA levels were significantly higher in group B patients than the control and group A. Prolidase activity was significantly lower than control group in total COPD groups (P < .05). There was a weak negative correlation between SA and forced vital capacity (r = -0.217, P = .038) and forced expiratory volume in 1 second (FEV1) (r = -0.210, P = .045), whereas weak positive correlation was present between SA and Creactive protein (r = 0.247, P = .018) in all patient groups. There was weak positive correlation between prolidase and FEV1 (r = 0.222, P = .033) and FEV1/forced vital capacity (r = 0.230, P = .027).Our study shows that systemic inflammation, prolidase activity, and SA levels in stable COPD patients are associated with airflow obstruction severity. In addition to the prolidase activity; SA levels might be associated with inflammation.
我们这项研究的目的是评估唾液酸（SA）和脯氨酸酶活性的预后意义，并评估这些参数与慢性阻塞性肺疾病（COPD）患者气流阻塞严重程度之间的关系。本研究纳入了 94 名患者（84 名男性，10 名女性）和 34 名健康对照者（19 名男性，15 名女性）。根据包括肺功能检查、症状和住院情况在内的新全球倡议慢性阻塞性肺疾病标准，对 COPD 患者进行了 COPD 分期；将 COPD 患者分为 4 个亚组：A 组（n = 25）、B 组（n = 19）、C 组（n = 20）和 D 组（n = 28）。所有 COPD 组的 SA 和 C 反应蛋白水平均显著高于对照组。B 组患者的 SA 水平显著高于对照组和 A 组。所有 COPD 组的脯氨酸酶活性均显著低于对照组（P <.05）。在所有患者组中，SA 与用力肺活量（r = -0.217，P =.038）和 1 秒用力呼气量（FEV1）（r = -0.210，P =.045）呈弱负相关，而 SA 与 C 反应蛋白（r = 0.247，P =.018）呈弱正相关。在所有患者组中，脯氨酸酶与 FEV1（r = 0.222，P =.033）和 FEV1/用力肺活量（r = 0.230，P =.027）呈弱正相关。我们的研究表明，稳定期 COPD 患者的全身炎症、脯氨酸酶活性和 SA 水平与气流阻塞严重程度相关。除了脯氨酸酶活性外；SA 水平可能与炎症有关。
