Department of Minimally invasive Orthopaedics, Zhengzhou Orthopaedic Hospital, Zhengzhou, Henan, China,Department I of Neck, Shoulder, Waist and Leg pain, Zhengzhou Orthopaedic Hospital, Zhengzhou, Henan, China,Department of Preclinical, The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, China.
Medicine (Baltimore). 2022 Mar 18;101(11). doi: 10.1097/MD.0000000000029051.
After reduction and fixation of a fracture around the knee (FAK), excessive injury, improper treatment, soft tissue damage, and blood circulation damage often lead to limb dysfunction, which seriously affects limb rehabilitation and the patient's quality of life. Shaoyao Gancao Decoction (SGD) is an important means of treatment; however, it is not widely applied because of the lack of evidence about the effectiveness of oral drugs in the treatment of limb dysfunction. This study aimed to evaluate the effects of SGD on patients with limb dysfunction from the perspectives of pain, limb edema, stiffness, as well as physical dysfunction.
The Chinese and English databases, the Wanfang database, Cochrane Library, China National Knowledge Infrastructure, EMBASE, China BioMedical Literature, PubMed, and Web of Science will be searched from inception to September 30, 2021. Both researchers will select the articles, collect the data and evaluate the quality of the methodology independently using the Cochrane bias risk tool.
High-quality evidence will be obtained to evaluate the beneficial and detrimental effects of SGD on limb dysfunction after FAK, including knee pain, limb edema, stiffness, and physical dysfunction, as well as adverse events.
This study will provide evidence regarding whether SGD is beneficial for treating limb dysfunction after FAK in humans.
INPLASY202210028.
膝关节周围骨折（FAK）复位固定后，常因损伤过重、治疗不当、软组织损伤、血液循环障碍等导致肢体功能障碍，严重影响肢体康复和患者生活质量。芍药甘草汤（SGD）是治疗的重要手段之一，但由于口服药物治疗肢体功能障碍的疗效证据不足，尚未广泛应用。本研究旨在从疼痛、肢体肿胀、僵硬以及躯体功能障碍等方面，评价 SGD 对肢体功能障碍患者的治疗作用。
检索中国和英文数据库、万方数据库、 Cochrane Library、中国知网、EMBASE、中国生物医学文献数据库、PubMed 和 Web of Science，检索时间从建库至 2021 年 9 月 30 日。由 2 位研究者独立筛选文献、提取资料并评价方法学质量，采用 Cochrane 偏倚风险工具评价。
将获得高质量证据，评价 SGD 对 FAK 后肢体功能障碍的有益和有害作用，包括膝关节疼痛、肢体肿胀、僵硬和躯体功能障碍以及不良事件。
本研究将为 SGD 是否有益于治疗 FAK 后肢体功能障碍提供证据。
INPLASY202210028。
