乌头汤治疗类风湿关节炎的有效性和安全性：系统评价和/或荟萃分析方案。
The effectiveness and safety of Wu tou decoction on rheumatoid arthritis: A protocol for systematic review and/or meta-analysis.
机构信息
College of Korean Medicine, Dongguk University Graduate School, Seoul, South Korea,Department of Acupuncture & Moxibustion, Dongguk University Bundang Oriental Hospital, Gyeonggi-do, Republic of Korea,Department of Acupuncture & Moxibustion, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea,Department of Korean Neuropsychiatry, College of Korean Medicine, Sangji University, Gangwon-do, Republic of Korea,Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Sangji University, Gangwon-do, Republic of Korea,Institute of Oriental Medicine, College of Korean Medicine, Dongguk University, Goyang-si, Republic of Korea.
出版信息
Medicine (Baltimore). 2022 Mar 18;101(11). doi: 10.1097/MD.0000000000029105.
BACKGROUND
Rheumatoid arthritis (RA) is one of the common inflammatory diseases with arthritis due to a malfunction of the immune system. The treatments for RA include surgery, physiotherapy, occupational therapies, and medication. The representative treatment is medication and its usage has improved through several guidelines. However, it has some limitations and occurs adverse effects. Meanwhile, traditional Chinese medicine treatments have been used for RA treatment and Wu tou decoction (WTD) is one of them. Regardless of recent studies about WTD's efficacy on RA, there has been no systematic review on this issue. Therefore, this review will focus on the effectiveness and safety of WTD on RA.
METHODS
The search for randomized controlled trial about WTD on RA will be performed using multiple electronic databases, manual searches, and the author's e-mail if necessary. According to predefined criteria, randomized controlled trials will be selected and summarization will be performed by the data on study participants, result measurements, interventions, adverse events, and risk of bias. Disease activity score including effective rate, swollen joint count, tender joint count, morning stiffness will be primary outcome measures while blood test about RA including erythrocyte sedimentation rate, C-reactive protein, rheumatoid factors, and adverse events will be secondary outcome measures. We will perform meta-analysis by using Review Manager software, assess the risk of bias by Cochrane Collaboration "risk of bias" tool, and determine the quality of evidence by Grades of Recommendation, Assessment, Development, and Evaluation.
RESULTS
This study we will investigate the clinical evidence of the effectiveness and safety of WTD on RA.
CONCLUSION
For the RA patients and clinicians, our study will be informative. It can be also a great help for the researchers and policy makers who concentrates on conservative management for RA.
TRIAL REGISTRATION NUMBER
INPLASY; INPLASY202220099.
背景
类风湿关节炎（RA）是一种常见的炎症性疾病，其关节炎是由于免疫系统功能失调引起的。RA 的治疗包括手术、物理治疗、职业治疗和药物治疗。代表性的治疗方法是药物治疗，其使用已经通过几项指南得到了改善。然而，它存在一些局限性并会产生不良反应。同时，中医治疗已被用于 RA 的治疗，乌头汤（WTD）就是其中之一。尽管最近有关于 WTD 对 RA 疗效的研究，但针对这个问题还没有系统评价。因此，本综述将重点关注 WTD 治疗 RA 的有效性和安全性。
方法
将使用多个电子数据库、手动搜索以及必要时作者的电子邮件来搜索关于 WTD 治疗 RA 的随机对照试验。根据预设标准，将选择随机对照试验，并通过研究参与者、结果测量、干预措施、不良事件和偏倚风险的数据进行总结。疾病活动评分，包括有效率、肿胀关节计数、压痛关节计数、晨僵，将是主要的结局测量指标，而 RA 的血液检查，包括红细胞沉降率、C 反应蛋白、类风湿因子和不良事件，将是次要的结局测量指标。我们将使用 Review Manager 软件进行荟萃分析，使用 Cochrane 协作“风险偏倚”工具评估偏倚风险，并通过推荐评估、发展和评价（GRADE）确定证据质量。
结果
本研究将调查 WTD 治疗 RA 的临床疗效和安全性的临床证据。
结论
对于 RA 患者和临床医生来说，我们的研究将具有信息性。它也将对专注于 RA 保守治疗的研究人员和政策制定者有很大帮助。
注册编号
INPLASY；INPLASY202220099。
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