慢性抗精神病药物治疗后多巴胺激动剂对运动活动的差异性增强作用：迟发性运动障碍的动物模型

Differential enhancement of locomotor activity by dopamine agonists following chronic neuroleptic treatment: an animal model of tardive dyskinesia.

作者信息

Tye N C, Horsman L, Wright F C, Pullar I A

出版信息

Eur J Pharmacol. 1979 Apr 1;55(1):103-7. doi: 10.1016/0014-2999(79)90153-5.

Abstract

Animals were administered clozapine or haloperidol for 22 days. Following treatment they were challenged with an apomorphine ester or lergotrile. Only haloperidol-treated animals exhibited significantly enhanced responses to apomorphine ester whereas administration of lergotrile potentiated locomotor activity in both treated groups. The results suggest that the use of different dopaminergic agonists may help to dissociate receptor supersensitivity arising from the antipsychotic actions of neuroleptics from that leading to the development of undesirable side effects.

摘要

给动物服用氯氮平或氟哌啶醇22天。治疗后，用阿扑吗啡酯或麦角腈对它们进行激发试验。只有接受氟哌啶醇治疗的动物对阿扑吗啡酯的反应显著增强，而在两个治疗组中，麦角腈的给药均增强了运动活性。结果表明，使用不同的多巴胺能激动剂可能有助于将抗精神病药物的抗精神病作用引起的受体超敏反应与导致不良副作用发生的受体超敏反应区分开来。