慢性吗啡治疗后多巴胺激动剂对运动活性的差异性增强作用。
Differential enhancement of locomotor activity by dopamine agonists following chronic morphine treatment.
作者信息
Tye N C, Horsman L, Wright F C, Pullar I A
出版信息
Psychopharmacology (Berl). 1979 May 15;63(3):313-5. doi: 10.1007/BF00433570.
PMID:39310
Abstract
Aniamls were administered increasing doses of morphine for 16 days. During withdrawal they were challenged with an apomorphine ester or lergotrile. These dopamine agonists produced quantitatively different effects on behaviour. The results suggest that chronic morphine administration leads to dopamine supersensitivity which may be anatomically distinct in origin.
摘要
给动物连续16天给予递增剂量的吗啡。在戒断期间，用阿扑吗啡酯或麦角腈对它们进行激发试验。这些多巴胺激动剂对行为产生了数量上不同的影响。结果表明，长期给予吗啡会导致多巴胺超敏反应，其起源在解剖学上可能是不同的。
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