Harris E N, Chan J K, Asherson R A, Aber V R, Gharavi A E, Hughes G R
Arch Intern Med. 1986 Nov;146(11):2153-6.
To determine the predictive value of the IgG anticardiolipin antibody (ACA) test for thrombosis, recurrent fetal loss, and thrombocytopenia, the clinical features of 121 patients with varying antibody levels were studied. When patients were grouped into high-positive, low-positive, and normal groups according to their ACA levels, there were strong statistical correlations with arterial thrombosis, venous thrombosis, fetal loss, thrombocytopenia, and a positive Coombs' test. At levels of 7 SD and above, the test was highly specific (greater than 80%) and predictive (greater than 70%) for thrombosis, thrombocytopenia, and recurrent fetal loss. This study suggests that the IgG ACA test may be a useful predictor for thrombosis, recurrent fetal loss, and thrombocytopenia in patients with autoimmune disorders.
为确定IgG抗心磷脂抗体（ACA）检测对血栓形成、复发性流产和血小板减少症的预测价值，对121例抗体水平各异的患者的临床特征进行了研究。当根据患者的ACA水平将其分为高阳性、低阳性和正常组时，与动脉血栓形成、静脉血栓形成、流产、血小板减少症及库姆斯试验阳性之间存在很强的统计学相关性。在7个标准差及以上水平时，该检测对血栓形成、血小板减少症和复发性流产具有高度特异性（大于80%）和预测性（大于70%）。本研究表明，IgG ACA检测可能是自身免疫性疾病患者血栓形成、复发性流产和血小板减少症的有用预测指标。
