Wang Xinchao, Wang Hang, Zhou Chunlin, Yang Lei, Fu Lei, Li Gang
College of Chemistry and Materials Science, Fujian Normal University, Fuzhou 350117, China.
Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Fuzhou, Fujian 350002, China.
Chem Commun (Camb). 2022 Apr 19;58(32):4993-4996. doi: 10.1039/d2cc00459c.
The use of a native directing group to promote C-H activation is highly desirable. Herein, we report a method of native carboxyl-assisted, Pd(II)-catalyzed -C-H acetoxylation of both hydrocinnamic and phenylacetic acids that can be found in many biologically active molecules as the key moieties. Based on the broad scope and the application potential showcased with drug molecules, it is anticipated that this C-H acetoxylation reaction will find attractive applicability in future synthetic endeavors.
使用天然导向基团来促进C-H活化是非常可取的。在此，我们报道了一种天然羧基辅助、钯（II）催化的氢化肉桂酸和苯乙酸的β-C-H乙酰氧基化方法，这两种酸在许多生物活性分子中作为关键部分存在。基于该反应对药物分子所展示出的广泛适用范围和应用潜力，可以预期这种C-H乙酰氧基化反应在未来的合成研究中将具有引人注目的适用性。
