Meehan R T
Aviat Space Environ Med. 1986 Oct;57(10 Pt 1):960-5.
The effect of hypoxia (H) on plasma renin (PRA), aldosterone (PA), and arginine vasopressin levels (AVP) was evaluated during 6 h of mild exercise (treadmill: 0 grade, 1 mph). A crossover study was performed on seven male volunteers during steady state conditions of H2O, Na+ and K+ balance while breathing 12.5% O2 (PaO2 42 +/- 3 mm Hg) and room air (N, 21% O2). After exercise there were no significant differences in body weight, hematocrit, calculated plasma volumes, serum or urine osmolality, urine Na+ or K+ excretion or AVP. Mean arterial pressure (MAP) while exercising was reduced during hypoxia (86 +/- 2 vs. 92 +/- 4 mm Hg), p less than 0.05. Normal diurnal variation in serum cortisol was lost during exercise (N and H). Plasma renin and aldosterone levels fell with exercise in both groups: PRA N 3.3 to 2.4 vs. H 4.9 to 2.3 ng X ml-1 X h-1; PA N 6.5 to 2.8 vs. H 9.3 to 2.3 ng X dl-1 (p less than 0.05). Hypoxia per se did not exert influence beyond mild exercise regarding serum osmolality, urine osmolality or Na+ or K+ excretion. Sustained hypoxia during 6 h of mild exercise despite a lower MAP failed to elevate PRA, aldosterone, or AVP levels when normal hydration is maintained.
在轻度运动（跑步机：0坡度，1英里/小时）6小时期间，评估了低氧（H）对血浆肾素（PRA）、醛固酮（PA）和精氨酸加压素水平（AVP）的影响。对7名男性志愿者进行了一项交叉研究，研究在H2O、Na+和K+平衡的稳态条件下进行，期间他们呼吸12.5%的氧气（动脉血氧分压42±3毫米汞柱）和室内空气（N，21%氧气）。运动后，体重、血细胞比容、计算得出的血浆容量、血清或尿渗透压、尿Na+或K+排泄量或AVP均无显著差异。低氧期间运动时的平均动脉压（MAP）降低（86±2对92±4毫米汞柱），p<0.05。运动期间（N和H）血清皮质醇正常的昼夜变化消失。两组运动时血浆肾素和醛固酮水平均下降：PRA N组从3.3降至2.4，H组从4.9降至2.3纳克·毫升-1·小时-1；PA N组从6.5降至2.8，H组从9.3降至2.3纳克·分升-1（p<0.05）。就血清渗透压、尿渗透压或Na+或K+排泄而言，低氧本身在轻度运动之外未产生影响。在轻度运动6小时期间持续低氧，尽管MAP较低，但在维持正常水合状态时未能提高PRA、醛固酮或AVP水平。
