Bancel B, Berger N, Pialat J, Sassolas G, Bornet H, Guillaud M, Tommasi M
Ann Pathol. 1986;6(3):176-82.
6 thyroid gland and 3 cervical lymph node clear-cells carcinomas are investigated by means of indirect immunofluorescence detection of thyroglobulin. Immunofluorescence was positive only in 1 case, which was a primitive thyroid carcinoma. In 7 other cases, its negativity pointed at the metastatic nature of the lesion, from a clear cell carcinoma of kidney (in 4 cases, nephrectomy was very remote, and in 3 cases, the renal lesion was discovered after our examination of the thyroid tumour). One observation showed negative staining reaction, and was a propagation of a parathyroid carcinoma to the thyroid gland. It is concluded that thyroglobulin can be used as an immunohistochemical marker to establish whether a clear cell cervical tumour originates from thyroid gland, or is a metastatic neoplasm.
通过甲状腺球蛋白的间接免疫荧光检测，对6例甲状腺和3例颈部淋巴结透明细胞癌进行了研究。仅1例免疫荧光呈阳性，该病例为原发性甲状腺癌。在其他7例病例中，其阴性结果表明病变具有转移性，原发于肾透明细胞癌（4例中肾切除术时间非常久远，3例中肾病变是在我们检查甲状腺肿瘤后才发现的）。1例观察结果显示染色反应阴性，是甲状旁腺癌转移至甲状腺。结论是，甲状腺球蛋白可用作免疫组织化学标志物，以确定颈部透明细胞瘤是起源于甲状腺，还是转移性肿瘤。
