Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China.
Department of Stomatology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China.
Clin Immunol. 2022 Apr;237:108989. doi: 10.1016/j.clim.2022.108989. Epub 2022 Mar 28.
Primary Sjögren's Disease (pSjD) is considered a B cell-mediated disease. Toll-like receptor 10 (TLR10) is highly expressed in human B cells, indicating that TLR10 probably plays a vital role in pSjD. We examined TLR10 expression in peripheral B subsets of pSjD patients and analyzed their association with disease activity. We observed that TLR10 expression in total, naïve, memory, and switched memory B cells was significantly increased in low-activity pSjD patients as compared with healthy controls and high-activity patients. TLR10 expression in the above mentioned B subsets (except naïve B) was negatively correlated with serum levels of anti-SSA antibody and BAFF, respectively. Moreover, a higher proportion of high-activity pSjD patients was observed in TLR10 low- than high-expressed patients. Our study concluded that TLR10 expression in CD19 B and memory B was negatively correlated with pSjD disease activity, suggesting that TLR10 might take part in the progression of pSjD.
原发性干燥综合征（pSjD）被认为是一种 B 细胞介导的疾病。Toll 样受体 10（TLR10）在人类 B 细胞中高度表达，表明 TLR10 可能在 pSjD 中发挥重要作用。我们检测了 pSjD 患者外周血 B 细胞亚群中 TLR10 的表达，并分析了其与疾病活动度的关系。结果发现，与健康对照组和高疾病活动度组相比，低疾病活动度 pSjD 患者的总 B 细胞、幼稚 B 细胞、记忆 B 细胞和转换记忆 B 细胞中的 TLR10 表达显著增加。上述 B 细胞亚群（除幼稚 B 细胞外）中的 TLR10 表达与血清抗 SSA 抗体和 BAFF 水平呈负相关。此外，在 TLR10 低表达患者中，高疾病活动度 pSjD 患者的比例较高。本研究表明，CD19+B 和记忆 B 细胞中的 TLR10 表达与 pSjD 疾病活动度呈负相关，提示 TLR10 可能参与了 pSjD 的进展。
