Sales Luciana Solera, Miranda Marina Lins, de Oliveira Analú Barros, Ferrisse Túlio Morandin, Fontana Carla Raquel, Milward Michael, Brighenti Fernanda Lourenção
Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, São Paulo State University (Unesp), School of Dentistry, R. Humaitá, 1680 - Centro, Araraquara, São Paulo 14801-903, Brazil.
São Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil; Department of Dental Materials and Prosthesis, São Paulo State University (Unesp), School of Dentistry, R. Humaitá, 1680 - Centro, Araraquara, São Paulo 14801-903, Brazil.
Arch Oral Biol. 2022 Jun;138:105425. doi: 10.1016/j.archoralbio.2022.105425. Epub 2022 Mar 25.
The present study aimed to conduct a systematic review of the literature, to evaluate, in vitro, the effectiveness of the technique of photodynamic therapy against microorganisms associated with periodontal disease.
This systematic review was carried out in accordance with the items on the PRISMA checklist and Cochrane guidelines. Only in vitro studies that evaluated the effect of the technique of antimicrobial photodynamic therapy on periodontopathogenic microorganisms were included.
A total of 32 articles published between 2000 and 2021 were included for qualitative analysis. For microorganisms in suspension, 25 studies (78.12%) showed a reduction greater than or equal to 3 logs CFU/mL of species associated with periodontal disease. In biofilms, three studies (42.7%) showed a reduction greater than or equal to 3 logs CFU/mL.
The results showed that the technique of photodynamic therapy may be a promising alternative to conventional antimicrobial approaches for reducing bacteria closely associated with periodontal disease. Some parameters (pre-irradiation time, type of photosensitizer, standardization of light parameters) need to be better established before conducting clinical studies.
本研究旨在对文献进行系统综述，以体外评估光动力疗法针对与牙周疾病相关微生物的有效性。
本系统综述按照PRISMA清单和Cochrane指南中的条目进行。仅纳入评估抗菌光动力疗法技术对牙周病原微生物作用效果的体外研究。
总共纳入了2000年至2021年间发表的32篇文章进行定性分析。对于悬浮状态的微生物，25项研究（78.12%）显示与牙周疾病相关菌种的减少量大于或等于3个对数CFU/mL。在生物膜中，3项研究（42.7%）显示减少量大于或等于3个对数CFU/mL。
结果表明，光动力疗法技术可能是一种有前景的替代传统抗菌方法的手段，用于减少与牙周疾病密切相关的细菌。在开展临床研究之前，一些参数（照射前时间、光敏剂类型、光照参数标准化）需要进一步明确。
