Li J Q, Li J
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Zhonghua Gan Zang Bing Za Zhi. 2022 Feb 20;30(2):121-126. doi: 10.3760/cma.j.cn501113-20211027-00522.
Acute-on-chronic liver failure (ACLF) is a form of complex syndrome with acute deterioration of liver function that occurs on the basis of chronic liver disease, and is accompanied by hepatic and extrahepatic organ failure with high mortality rate. The short-term mortality rate of comprehensive internal medicine treatment is as high as 50%-90%. This paper summarizes the current common definitions and diagnostic criteria, early-warning prediction models, and pathogenesis of ACLF.
慢加急性肝衰竭（ACLF）是一种复杂的综合征，表现为在慢性肝病基础上肝功能急性恶化，并伴有肝内外器官衰竭，死亡率很高。综合内科治疗的短期死亡率高达50%-90%。本文总结了目前ACLF常见的定义、诊断标准、预警预测模型及发病机制。
