泛素特异性蛋白酶11（USP11）在癌症中的双重作用。

Guo Tuanjie, Tang Heting, Yuan Zhihao, Zhang Encheng, Wang Xiang

Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

J Oncol. 2022 Mar 22;2022:9963905. doi: 10.1155/2022/9963905. eCollection 2022.

Ubiquitination is one of the most crucial ways of protein degradation and plays an indispensable role in various living activities of cells. The deubiquitinating enzyme (DUB) is the main practitioner of the reversal of ubiquitination. Up till the present moment, nearly 100 DUBs from six families have been confirmed. USP11 is a member of the largest subfamily of cysteine protease DUBs, involving in the regulation of cell cycle, DNA repair, regulating signaling pathways, tumor development, and other important biological behaviors. This review briefly describes the structure and function of USP11 and comprehensively describes its dual role in tumorigenesis and development, as well as its targeted therapy.

泛素化是蛋白质降解的关键方式之一，在细胞的各种生命活动中发挥着不可或缺的作用。去泛素化酶（DUB）是泛素化逆转的主要执行者。截至目前，已确认来自六个家族的近100种DUB。USP11是半胱氨酸蛋白酶DUB最大亚家族的成员，参与细胞周期调控、DNA修复、信号通路调节、肿瘤发生等重要生物学行为。本文简要介绍了USP11的结构和功能，并全面阐述了其在肿瘤发生发展中的双重作用及其靶向治疗。