Li Zixuan, Yang Yuanyuan, Wu Kun, Li Yuntao, Shi Mingxia
Department of Hematology, the First Affiliated Hospital of Kunming Medical University, Kunming, China.
Hematology Research Center of Yunnan Province, Kunming, China.
Front Oncol. 2023 Feb 6;13:1124978. doi: 10.3389/fonc.2023.1124978. eCollection 2023.
The occurrence and development of malignancies are closely related to abnormal cell cycle regulation. Myeloid leukemia factor 1 (MLF1) is a small nucleocytoplasmic shuttling protein associated with cell cycle exit, apoptosis, and certain immune functions. Therefore, it is pertinent to explore the role of MLF1 in health and diseases. Studies to date have suggested that MLF1 could act as a double-edged sword, regulating biochemical activities directly or indirectly. In hematopoietic cells, it serves as a protective factor for the development of lineages, and in malignancies, it serves as an oncogenesis factor. The diversity of its functions depends on the binding partners, including tumor inhibitors, scaffolding molecules, mitochondrial membrane proteins, and transcription factors. Emerging evidence indicates that MLF1 influences immune responses as well. This paper reviews the structure, biological function, and research progress on MLF1 in health and diseases to provide new insights for future research.
恶性肿瘤的发生和发展与细胞周期调控异常密切相关。髓系白血病因子1（MLF1）是一种小的核质穿梭蛋白，与细胞周期退出、细胞凋亡及某些免疫功能相关。因此，探索MLF1在健康和疾病中的作用具有重要意义。迄今为止的研究表明，MLF1可能是一把双刃剑，直接或间接地调节生化活动。在造血细胞中，它是谱系发育的保护因子，而在恶性肿瘤中，它是肿瘤发生因子。其功能的多样性取决于结合伙伴，包括肿瘤抑制因子、支架分子、线粒体膜蛋白和转录因子。新出现的证据表明，MLF1也影响免疫反应。本文综述了MLF1在健康和疾病方面的结构、生物学功能及研究进展，为未来研究提供新的见解。
