Eghbalian Fatemeh, Shabani Somayeh, Faradmal Javad, Jenabi Ensiyeh
Division of Neonatology, Department of Pediatric, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Pediatrics, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Int J Pediatr. 2022 Mar 22;2022:5439630. doi: 10.1155/2022/5439630. eCollection 2022.
Neonatal jaundice or hyperbilirubinemia is one of the common findings in neonatal medicine. Severe disease can cause neurological damage and even Kernicterus. Magnesium ion is the most important N-methyl-D-aspartate receptor antagonist. The most commonly used treatment for jaundice is phototherapy, but the effect of phototherapy on serum magnesium is less investigated. In this study, we aim to investigate the effects of phototherapy on total serum magnesium levels in icteric neonates.
This prospective cohort study was carried out on 160 neonates with jaundice referring to the Besat Hospital of Hamadan. Based on the bilirubin level, newborns were divided into three subgroups of mild, moderate, and severe disease which were subjected to single, double, and intensive phototherapy, respectively. Serum bilirubin and magnesium levels were measured before and after phototherapy and compared using parametric tests.
Subjects have a mean intrauterine age of 38.8 weeks and a jaundice onset age of 3.8 days. In all groups, serum magnesium levels were within the normal range before phototherapy. After phototherapy, on the other hand, the most reduction of total serum magnesium was in the double phototherapy group, which was -0.13 ± 0.42 mg/dl ( = 0.018). The change in serum magnesium level was not significant in the single phototherapy (-0.02 ± 0.25) and intensive phototherapy (-13.55 ± 2.73) groups ( > 0.05).
In the present study, serum magnesium did not increase significantly before the treatment in three groups. After treatment, a significant reduction was seen in the double phototherapy group.
新生儿黄疸或高胆红素血症是新生儿医学中常见的病症之一。严重的疾病可导致神经损伤甚至核黄疸。镁离子是最重要的N-甲基-D-天冬氨酸受体拮抗剂。治疗黄疸最常用的方法是光疗，但光疗对血清镁的影响研究较少。在本研究中，我们旨在探讨光疗对黄疸新生儿血清总镁水平的影响。
本前瞻性队列研究对转诊至哈马丹贝萨特医院的160例黄疸新生儿进行。根据胆红素水平，新生儿被分为轻度、中度和重度疾病三个亚组，分别接受单光疗、双光疗和强化光疗。在光疗前后测量血清胆红素和镁水平，并使用参数检验进行比较。
研究对象的平均宫内年龄为38.8周，黄疸发病年龄为3.8天。在所有组中，光疗前血清镁水平均在正常范围内。另一方面，光疗后，双光疗组血清总镁下降最多，为-0.13±0.42mg/dl（P=0.018）。单光疗组（-0.02±0.25）和强化光疗组（-13.55±2.73）血清镁水平变化不显著（P>0.05）。
在本研究中，三组治疗前血清镁均未显著升高。治疗后，双光疗组出现显著下降。
