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光疗治疗新生儿黄疸的副作用:我们了解多少?我们应该怎么做?

The side effects of phototherapy for neonatal jaundice: what do we know? What should we do?

机构信息

Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.

出版信息

Eur J Pediatr. 2011 Oct;170(10):1247-55. doi: 10.1007/s00431-011-1454-1. Epub 2011 Apr 1.

DOI:10.1007/s00431-011-1454-1
PMID:21455834
Abstract

Neonatal phototherapy (NNPT), a noninvasive, easily available therapy, has been widely used for the treatment of neonatal jaundice for more than half a century. Its efficiency in decreasing plasma bilirubin concentration is well documented, and NNPT leads to greatly reduced exchange transfusion rates for neonates with hyperbilirubinemia. It is generally accepted that the side effects of NNPT are not serious and seem to be well controlled. This review will focus on these possible side effects as well as the approaches to minimize them.

摘要

新生儿光疗(NNPT)是一种非侵入性、易于获得的治疗方法,已经广泛应用于治疗新生儿黄疸超过半个世纪。其降低血浆胆红素浓度的效果已有充分记录,并且可以大大降低高胆红素血症新生儿换血的比率。通常认为,NNPT 的副作用并不严重,而且似乎可以得到很好的控制。本综述将重点讨论这些可能的副作用以及减轻这些副作用的方法。

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The side effects of phototherapy for neonatal jaundice: what do we know? What should we do?光疗治疗新生儿黄疸的副作用:我们了解多少?我们应该怎么做?
Eur J Pediatr. 2011 Oct;170(10):1247-55. doi: 10.1007/s00431-011-1454-1. Epub 2011 Apr 1.
2
Neonatal jaundice: update on phototherapy management.新生儿黄疸:光疗管理的最新进展
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Fundamentals of phototherapy for neonatal jaundice.新生儿黄疸的光疗基础
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Side Effects of Phototherapy on Neonates.光疗对新生儿的副作用。
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Phototherapy for neonatal hyperbilirubinemia--a potential environmental health hazard to newborn infants: a review.新生儿高胆红素血症的光疗——对新生儿潜在的环境健康危害:综述
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[Data on phototherapy in neonatal jaundice].[新生儿黄疸光疗的数据]
Arch Fr Pediatr. 1980 Jun;37(6):407-14.
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Bilirubin phototherapy and potential UVR hazards.胆红素光疗与潜在的紫外线辐射危害。
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[Treatment of neonatal jaundice by efficient phototherapy].[高效光疗治疗新生儿黄疸]
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Health Sci Rep. 2025 Jul 27;8(8):e71079. doi: 10.1002/hsr2.71079. eCollection 2025 Aug.
2
Hematological parameter changes and associated factors in neonates with hyperbilirubinemia treated with phototherapy.光疗治疗新生儿高胆红素血症的血液学参数变化及相关因素
BMC Pediatr. 2025 Feb 14;25(1):115. doi: 10.1186/s12887-025-05464-4.
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Hyperbilirubinemia and retinopathy of prematurity: a retrospective cohort study.

本文引用的文献

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Is there a role of early neonatal events in susceptibility to allergy?早期新生儿事件在过敏易感性中是否起作用?
Int J Biomed Sci. 2010 Mar;6(1):8-12.
2
The Effect of Clofibrate on Decreasing Serum Bilirubin in Healthy Term Neonates under Home Phototherapy.氯贝丁酯对居家光疗足月健康新生儿血清胆红素降低的影响。
Iran J Pediatr. 2010 Mar;20(1):48-52.
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Bilirubin, copper-porphyrins, and the bronze-baby syndrome.胆红素、铜卟啉和青铜婴儿综合征。
高胆红素血症与早产儿视网膜病变:一项回顾性队列研究。
Eur J Pediatr. 2024 Sep;183(9):3809-3818. doi: 10.1007/s00431-024-05630-3. Epub 2024 Jun 15.
4
Continuous versus intermittent phototherapy in treatment of neonatal jaundice: a randomized controlled trial.连续与间歇性光疗治疗新生儿黄疸:一项随机对照试验。
Eur J Pediatr. 2024 Aug;183(8):3389-3396. doi: 10.1007/s00431-024-05610-7. Epub 2024 May 20.
5
"Light" on Phototherapy-Complications and Strategies for Shortening Its Duration, A Review of the Literature.光疗的“亮点”——并发症及缩短疗程的策略,文献综述
Children (Basel). 2023 Oct 17;10(10):1699. doi: 10.3390/children10101699.
6
Efficacy of kangaroo mother care combined with neonatal phototherapy in newborns with non-pathological jaundice: A meta-analysis.袋鼠式护理联合新生儿光疗对非病理性黄疸新生儿的疗效:一项荟萃分析。
Front Pediatr. 2023 Jan 25;11:1098143. doi: 10.3389/fped.2023.1098143. eCollection 2023.
7
Cardiovascular changes during phototherapy in newborns.新生儿光疗期间的心血管变化。
Physiol Res. 2022 Dec 31;71(S2):S179-S186. doi: 10.33549/physiolres.935002.
8
Single-surface Intensive Phototherapy or Double-Surface Intensive Phototherapy in Neonatal Non-Hemolytic Hyperbilirubinemia: A Comparison of Effectiveness and Complications.单面强化光疗与双面强化光疗治疗新生儿非溶血性高胆红素血症的疗效及并发症比较
Med J Islam Repub Iran. 2021 Dec 31;35:192. doi: 10.47176/mjiri.35.192. eCollection 2021.
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Effects of Phototherapy on the Serum Magnesium Level in Neonates with Indirect Hyperbilirubinemia: A Prospective Cohort Study.光疗对间接胆红素血症新生儿血清镁水平的影响:一项前瞻性队列研究
Int J Pediatr. 2022 Mar 22;2022:5439630. doi: 10.1155/2022/5439630. eCollection 2022.
10
The Effects of Clofibrate on Neonatal Jaundice: A Systematic Review.氯贝丁酯对新生儿黄疸的影响:一项系统评价
Int J Prev Med. 2022 Jan 19;13:3. doi: 10.4103/ijpvm.IJPVM_407_20. eCollection 2022.
J Pediatr. 2011 Jan;158(1):160-4. doi: 10.1016/j.jpeds.2010.08.014.
4
NICE guidelines on neonatal jaundice: at risk of being too nice.英国国家卫生与临床优化研究所(NICE)关于新生儿黄疸的指南:可能过于宽松
Lancet. 2010 Sep 4;376(9743):771. doi: 10.1016/S0140-6736(10)61376-1.
5
Are recommended phototherapy thresholds safe enough for extremely low birth weight (ELBW) infants? A report on 2 ELBW infants with kernicterus despite only moderate hyperbilirubinemia.推荐的光疗阈值对极低出生体重(ELBW)婴儿足够安全吗?报告 2 例 ELBW 婴儿即使仅有中度高胆红素血症也发生核黄疸。
Neonatology. 2011;99(2):90-4. doi: 10.1159/000302719. Epub 2010 Jul 17.
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Twists and turns in phototherapy for neonatal jaundice.新生儿黄疸光疗的曲折历程。
Acta Paediatr. 2010 Aug;99(8):1117-8. doi: 10.1111/j.1651-2227.2010.01898.x. Epub 2010 May 29.
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Neonatal jaundice: summary of NICE guidance.新生儿黄疸:英国国家卫生与临床优化研究所(NICE)指南总结
BMJ. 2010 May 19;340:c2409. doi: 10.1136/bmj.c2409.
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Incidence and risk factors of retinopathy of prematurity in Babol, North of Iran.伊朗北部巴博勒地区早产儿视网膜病变的发病率及危险因素
Ophthalmic Epidemiol. 2010 Jun;17(3):166-70. doi: 10.3109/09286581003734860.