Campos Laise M, Guapyassu Livia, Gomes Cyro, Midlej Victor, Benchimol Marlene, Mermelstein Claudia, Costa Manoel Luis
Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.
Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Front Cell Dev Biol. 2022 Mar 14;10:778901. doi: 10.3389/fcell.2022.778901. eCollection 2022.
Simvastatin is one of the most common medicines prescribed to treat human hypercholesterolemia. Simvastatin acts through the inhibition of cholesterol synthesis. Unfortunately, simvastatin causes unwanted side effects on muscles, such as soreness, tiredness, or weakness. Therefore, to understand the mechanism of action of simvastatin, it is important to study its physiological and structural impacts on muscle in varied animal models. Here we report on the effects of simvastatin on two biological models: zebrafish embryos and chicken muscle culture. In the last years, our group and others showed that simvastatin treatment in zebrafish embryos reduces fish movements and induces major structural alterations in skeletal muscles. We also showed that simvastatin and membrane cholesterol depletion induce major changes in proliferation and differentiation of muscle cells in chick muscle cultures. Here, we review and discuss these observations considering reported data on the use of simvastatin as a potential therapy for Duchenne muscular dystrophy.
辛伐他汀是治疗人类高胆固醇血症最常用的药物之一。辛伐他汀通过抑制胆固醇合成发挥作用。不幸的是，辛伐他汀会对肌肉产生不良副作用，如酸痛、疲劳或无力。因此，为了解辛伐他汀的作用机制，在不同动物模型中研究其对肌肉的生理和结构影响很重要。在此，我们报告辛伐他汀对两种生物学模型的影响：斑马鱼胚胎和鸡肌肉培养物。在过去几年中，我们团队和其他研究表明，在斑马鱼胚胎中使用辛伐他汀会减少鱼的活动，并导致骨骼肌出现重大结构改变。我们还表明，辛伐他汀和膜胆固醇耗竭会引起鸡肌肉培养物中肌肉细胞增殖和分化的重大变化。在此，我们结合已报道的关于辛伐他汀作为杜氏肌营养不良潜在治疗方法的数据，对这些观察结果进行综述和讨论。
