Wang Jian-Peng, Li Chong, Ding Wen-Cong, Peng Gang, Xiao Ge-Lei, Chen Rui, Cheng Quan
Department of Neurosurgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Front Mol Neurosci. 2022 Mar 10;15:835012. doi: 10.3389/fnmol.2022.835012. eCollection 2022.
Globally, traumatic brain injury (TBI) is an acute clinical event and an important cause of death and long-term disability. However, the underlying mechanism of the pathophysiological has not been fully elucidated and the lack of effective treatment a huge burden to individuals, families, and society. Several studies have shown that long non-coding RNAs (lncRNAs) might play a crucial role in TBI; they are abundant in the central nervous system (CNS) and participate in a variety of pathophysiological processes, including oxidative stress, inflammation, apoptosis, blood-brain barrier protection, angiogenesis, and neurogenesis. Some lncRNAs modulate multiple therapeutic targets after TBI, including inflammation, thus, these lncRNAs have tremendous therapeutic potential for TBI, as they are promising biomarkers for TBI diagnosis, treatment, and prognosis prediction. This review discusses the differential expression of different lncRNAs in brain tissue during TBI, which is likely related to the physiological and pathological processes involved in TBI. These findings may provide new targets for further scientific research on the molecular mechanisms of TBI and potential therapeutic interventions.
在全球范围内，创伤性脑损伤（TBI）是一种急性临床事件，也是死亡和长期残疾的重要原因。然而，其病理生理的潜在机制尚未完全阐明，且缺乏有效治疗方法给个人、家庭和社会带来了巨大负担。多项研究表明，长链非编码RNA（lncRNAs）可能在TBI中起关键作用；它们在中枢神经系统（CNS）中大量存在，并参与多种病理生理过程，包括氧化应激、炎症、细胞凋亡、血脑屏障保护、血管生成和神经发生。一些lncRNAs在TBI后调节多个治疗靶点，包括炎症，因此，这些lncRNAs对TBI具有巨大的治疗潜力，因为它们有望成为TBI诊断、治疗和预后预测的生物标志物。本综述讨论了TBI期间脑组织中不同lncRNAs的差异表达，这可能与TBI所涉及的生理和病理过程有关。这些发现可能为进一步开展TBI分子机制的科学研究和潜在治疗干预提供新的靶点。
