Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Feb 28;46(2):183-188. doi: 10.11817/j.issn.1672-7347.2021.190702.
Traumatic brain injury (TBI) is a main cause of death and disability worldwide, posing a serious threat to public health. But currently, the diagnosis and treatments for TBI are still very limited. Exosomes are a group of extracellular vesicles and participate in multiple physiological processes including intercellular communication and substance transport. Non-coding RNAs (ncRNA) are of great abundancy as cargo of exosomes. Previous studies have shown that ncRNAs are involved in several pathophysiological processes of TBI. However, the concrete mechanisms involved in the effects induced by exosome-derived ncRNA remain largely unknown. As an important component of exosomes, ncRNA is of great significance for diagnosis, precise treatment, response evaluation, prognosis prediction, and complication management after TBI.
创伤性脑损伤（TBI）是全球范围内死亡和残疾的主要原因，对公众健康构成严重威胁。但是目前，TBI 的诊断和治疗仍然非常有限。外泌体是一组细胞外囊泡，参与包括细胞间通讯和物质运输在内的多种生理过程。非编码 RNA（ncRNA）作为外泌体的货物大量存在。先前的研究表明，ncRNA 参与了 TBI 的几个病理生理过程。然而，外泌体衍生的 ncRNA 所诱导的作用涉及的具体机制在很大程度上仍然未知。作为外泌体的重要组成部分，ncRNA 对于 TBI 后的诊断、精确治疗、反应评估、预后预测和并发症管理具有重要意义。
