Ionescu Cătălina, Ghidersa Madalina, Ciobica Alin, Mavroudis Ioannis, Kazis Dimitrios, Petridis Foivos E, Gorgan Dragoș Lucian, Balmus Ioana-Miruna
Department of Biology, Faculty of Biology, "Alexandru Ioan Cuza" University of Iasi, 700505 Iasi, Romania.
"Ioan Haulica" Institute, Apollonia University, 700511 Iasi, Romania.
Int J Mol Sci. 2025 Apr 18;26(8):3858. doi: 10.3390/ijms26083858.
Diagnosing traumatic brain injury (TBI) remains challenging due to an incomplete understanding of its neuropathological mechanisms. TBI is recognised as a complex condition involving both primary and secondary injuries. Although oxidative stress is a non-specific molecular phenomenon observed in various neuropathological conditions, it plays a crucial role in brain injury response and recovery. Due to these aspects, we aimed to evaluate the interaction between some known TBI molecular biomarkers and oxidative stress in providing evidence for its possible relevance in clinical diagnosis and outcome prediction. We found that while many of the currently validated molecular biomarkers interact with oxidative pathways, their patterns of variation could assist the diagnosis, prognosis, and outcomes prediction in TBI cases.
由于对创伤性脑损伤（TBI）神经病理机制的认识不完整，其诊断仍然具有挑战性。TBI被认为是一种涉及原发性和继发性损伤的复杂病症。尽管氧化应激是在各种神经病理状况中观察到的一种非特异性分子现象，但它在脑损伤反应和恢复中起着至关重要的作用。基于这些方面，我们旨在评估一些已知的TBI分子生物标志物与氧化应激之间的相互作用，为其在临床诊断和结果预测中的潜在相关性提供证据。我们发现，虽然目前许多经过验证的分子生物标志物与氧化途径相互作用，但其变化模式有助于TBI病例的诊断、预后和结果预测。
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