Wen Dongsheng, Gao Ya, Ho Chiakang, Yu Li, Zhang Yuguang, Lyu Guozhong, Hu Dahai, Li Qingfeng, Zhang Yifan
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Burns and Plastic Surgery, Affiliated Hospital of Jiangnan University, Wuxi, China.
Front Mol Biosci. 2022 Mar 11;9:804680. doi: 10.3389/fmolb.2022.804680. eCollection 2022.
Fibrosis, a pathologic process featured by the excessive deposition of connective tissue components, can affect virtually every organ and has no satisfactory therapy yet. Fibrotic diseases are often associated with organ dysfunction which leads to high morbidity and mortality. Biomechanical stmuli and the corresponding cellular response havebeen identified in fibrogenesis, as the fibrotic remodeling could be seen as the incapacity to reestablish mechanical homeostasis: along with extracellular matrix accumulating, the physical property became more "stiff" and could in turn induce fibrosis. In this review, we provide a comprehensive overview of mechanoregulation in fibrosis, from initialing cellular mechanosensing to intracellular mechanotransduction and processing, and ends up in mechanoeffecting. Our contents are not limited to the cellular mechanism, but further expand to the disorders involved and current clinical trials, providing an insight into the disease and hopefully inspiring new approaches for the treatment of tissue fibrosis.
纤维化是一种以结缔组织成分过度沉积为特征的病理过程，几乎可影响每个器官，且目前尚无令人满意的治疗方法。纤维化疾病常与器官功能障碍相关，导致高发病率和死亡率。生物力学刺激及相应的细胞反应已在纤维化形成过程中得到确认，因为纤维化重塑可被视为无法重新建立机械稳态：随着细胞外基质的积累，物理性质变得更“硬”，进而可诱导纤维化。在本综述中，我们全面概述了纤维化中的机械调节，从初始的细胞机械感知到细胞内机械转导和处理，最终到机械效应。我们的内容不仅限于细胞机制，还进一步扩展到所涉及的疾病和当前的临床试验，以深入了解该疾病，并有望启发治疗组织纤维化的新方法。
