Zhang Li-Li, Zhang Liang, Dong Jingde, Zhao Ying, Wang Xiao-Ping
Shanghai General Hospital of Nanjing Medical University, Shanghai, China.
Department of Geriatrics, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Front Neurol. 2022 Mar 11;13:816315. doi: 10.3389/fneur.2022.816315. eCollection 2022.
Little is known about the nutritional status and clinical characteristics of patients with Parkinson's disease with freezing of gait (PDFOG). The purpose of this study was to describe the relationship between nutritional status and characteristics of patients with PDFOG.
In this cross-sectional study, 178 PDFOG patients were recruited and classified as nutritionally normal or at risk of malnutrition/already malnourished based on their Mini Nutritional Assessment (MNA) scores. Each participant underwent a structured questionnaire, physical examination and routine serum biochemical tests.
We found that 44.4 and 37.1% of PDFOG patients were malnourished [mini nutritional assessment (MNA) score <17] and at risk of malnutrition (17 ≤ MNA score ≤ 23.5), respectively. Compared to patients with normal nutrition, PDFOG patients with malnutrition and at risk of malnutrition had longer duration of Parkinson's disease (PD) and freezing of gait (FOG), more levodopa equivalent daily doses (LEDD), lower body mass index (BMI), more motor symptoms according to the Unified PD Rating Scale-III (UPDRS-III) and non-motor symptoms according to the PD Non-motor Symptoms Questionnaire (PD-NMS) ( < 0.05). Uric acid, albumin, prealbumin, and total cholesterol (TC) differed between the two groups ( < 0.05). High Hoehn and Yahr (H-Y) stage, high Freezing of Gait Questionnaire (FOGQ) scores, low TC and low uric acid were risk factors for malnutrition in patients with PDFOG.
Our results showed disease severity, motor symptoms, TC levels and uric acid levels were all associated with nutritional status in patients with PDFOG. This study suggest early discovery of the nutritional status of PDFOG patients is important.
关于帕金森病伴冻结步态（PDFOG）患者的营养状况和临床特征，人们了解甚少。本研究的目的是描述PDFOG患者营养状况与特征之间的关系。
在这项横断面研究中，招募了178例PDFOG患者，并根据其微型营养评定法（MNA）评分将其分为营养正常或有营养不良风险/已营养不良。每位参与者都接受了结构化问卷调查、体格检查和常规血清生化检测。
我们发现，分别有44.4%和37.1%的PDFOG患者存在营养不良（微型营养评定法[MNA]评分<17）和有营养不良风险（17≤MNA评分≤23.5）。与营养正常的患者相比，存在营养不良和有营养不良风险的PDFOG患者帕金森病（PD）病程和冻结步态（FOG）持续时间更长，左旋多巴等效日剂量（LEDD）更多，体重指数（BMI）更低，根据统一帕金森病评定量表第三部分（UPDRS-III）的运动症状更多，根据帕金森病非运动症状问卷（PD-NMS）的非运动症状更多（<0.05）。两组之间尿酸、白蛋白、前白蛋白和总胆固醇（TC）存在差异（<0.05）。高霍恩和雅尔（H-Y）分期、高冻结步态问卷（FOGQ）评分、低TC和低尿酸是PDFOG患者营养不良的危险因素。
我们的结果表明，疾病严重程度、运动症状、TC水平和尿酸水平均与PDFOG患者的营养状况相关。本研究表明，早期发现PDFOG患者的营养状况很重要。
