Tomic Svetlana, Pekic Vlasta, Popijac Zeljka, Pucic Tomislav, Petek Marta, Kuric Tihana Gilman, Misevic Sanja, Kramaric Ruzica Palic
Clinical Department of Neurology, Osijek University Hospital Center, Osijek, Croatia; School of Medicine, Josip Juraj Strossmayer University in Osijek, Osijek, Croatia.
Clinical Department of Neurology, Osijek University Hospital Center, Osijek, Croatia; School of Medicine, Josip Juraj Strossmayer University in Osijek, Osijek, Croatia.
J Neurol Sci. 2017 Apr 15;375:235-238. doi: 10.1016/j.jns.2017.01.070. Epub 2017 Feb 1.
Parkinson's disease (PD) patients are at a higher risk of malnutrition. The prevalence has been estimated to 0-24%, while 3%-60% of PD patients are reported to be at risk of malnutrition. To date, there is no clear explanation for malnutrition in these patients. The aim of this study was to determine the prevalence of malnutrition and to analyze factors that influence its appearance. The Mini Nutritional Assessment (MNA) was used to determine normal nutritional status; at risk of malnutrition; and already malnourished status. The Unified Parkinson's Disease Rating Scale (UPDRS) parts III and IV, Hoehn and Yahr scale (H&Y scale), Beck Depression Inventory (BDI), Mini Mental State Examination (MMSE), Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale - eating part (QUIP-RS) and Mini Nutritional Assessment (MNA) were used to evaluate the factors affecting patient nutritional status. Out of 96 patients, 55,2% were at risk of malnutrition, while 8,3% had already been malnourished. Age, H&Y scale, UPDRS part III, 'off' periods and depression influence negatively on MNA. More patients with 'off' periods were rigor dominant. Thyroid gland hormone therapy was related to malnutrition, while patients with normal nutritional status used ropinirole more often than pramipexole. Factors affecting nutritional status are age, motor symptoms and stage severity, 'off' states, rigidity dominant type with 'off' states, and thyroid hormone replacement therapy. Ropinirole exhibited the possible 'protective' effect against malnutrition.
帕金森病（PD）患者存在更高的营养不良风险。据估计，其患病率为0%-24%，而据报道3%-60%的PD患者有营养不良风险。迄今为止，对于这些患者的营养不良尚无明确解释。本研究的目的是确定营养不良的患病率，并分析影响其出现的因素。采用微型营养评定法（MNA）来确定正常营养状况、有营养不良风险和已患营养不良的状况。使用统一帕金森病评定量表（UPDRS）第三部分和第四部分、霍恩和雅尔分级量表（H&Y量表）、贝克抑郁量表（BDI）、简易精神状态检查表（MMSE）、帕金森病冲动控制障碍问卷-进食部分评定量表（QUIP-RS）和微型营养评定法（MNA）来评估影响患者营养状况的因素。在96例患者中，55.2%有营养不良风险，而8.3%已患营养不良。年龄、H&Y量表、UPDRS第三部分、“关”期和抑郁对MNA有负面影响。更多处于“关”期的患者以僵直为主。甲状腺激素治疗与营养不良有关，而营养状况正常的患者使用罗匹尼罗的频率高于普拉克索。影响营养状况的因素有年龄、运动症状和疾病严重程度、“关”期状态、以僵直为主型伴“关”期状态以及甲状腺激素替代治疗。罗匹尼罗对营养不良可能具有“保护”作用。
