Post R M, Rubinow D R, Ballenger J C
Br J Psychiatry. 1986 Aug;149:191-201. doi: 10.1192/bjp.149.2.191.
Few biological theories of manic-depressive illness have focused on the longitudinal course of affective dysfunction and the mechanisms underlying its often recurrent and progressive course. The authors discuss two models for the development of progressive behavioural dysfunction--behavioural sensitisation and electrophysiological kindling--as they provide clues to important clinical and biological variables relevant to sensitisation in affective illness. The role of environmental context and conditioning in mediating behavioural and biochemical aspects of this sensitisation is emphasised. The sensitisation models provide a conceptual approach to previously inexplicable clinical phenomena in the longitudinal course of affective illness and may provide a bridge between psychoanalytic/psychosocial and neurobiological formulations of manic-depressive illness.
很少有关于躁郁症的生物学理论关注情感功能障碍的纵向病程以及其经常复发和进展过程背后的机制。作者讨论了两种进行性行为功能障碍发展的模型——行为敏化和电生理点燃——因为它们为情感疾病中与敏化相关的重要临床和生物学变量提供了线索。强调了环境背景和条件作用在介导这种敏化的行为和生化方面的作用。敏化模型为情感疾病纵向病程中以前无法解释的临床现象提供了一种概念性方法，并且可能在躁郁症的精神分析/心理社会和神经生物学表述之间架起一座桥梁。
