Phillips Cristy
Department of Physical Therapy, A-State, Jonesboro, AR, USA.
Neural Plast. 2017;2017:7014146. doi: 10.1155/2017/7014146. Epub 2017 Apr 26.
Mood disorders (MDs) are chronic, recurrent mental diseases that affect millions of individuals worldwide. Although the biogenic amine model has provided some clinical utility, a need remains to better understand the interrelated mechanisms that contribute to neuroplasticity deficits in MDs and the means by which various therapeutics mitigate them. Of those therapeutics being investigated, physical activity (PA) has shown clear and consistent promise. Accordingly, the aims of this review are to (1) explicate key modulators, processes, and interactions that impinge upon multiple susceptibility points to effectuate neuroplasticity deficits in MDs; (2) explore the putative mechanisms by which PA mitigates these features; (3) review protocols used to induce the positive effects of PA in MDs; and (4) highlight implications for clinicians and researchers.
情绪障碍（MDs）是慢性复发性精神疾病，影响着全球数百万人。尽管生物胺模型已具有一定临床应用价值，但仍需要更好地理解导致MDs神经可塑性缺陷的相关机制，以及各种治疗方法缓解这些缺陷的方式。在正在研究的那些治疗方法中，体育活动（PA）已显示出明确且一致的前景。因此，本综述的目的是：（1）阐明影响多个易感性点从而导致MDs神经可塑性缺陷的关键调节因子、过程和相互作用；（2）探索PA减轻这些特征的潜在机制；（3）回顾用于诱导PA对MDs产生积极影响的方案；（4）强调对临床医生和研究人员的启示。
