International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China.
Front Endocrinol (Lausanne). 2022 Mar 14;13:826665. doi: 10.3389/fendo.2022.826665. eCollection 2022.
To evaluate the association between paternal obesity and fetal development and pregnancy complications.
This prospective cohort clinical trial analyzed data from 7683 women with singleton pregnancies. All study subjects were sequentially divided into four groups based on paternal BMI. We compared the differences in fetal growth and pregnancy complications between different paternal BMI groups by univariate logistic regression and independent t-test. Finally, the independent predictors of SGA and macrosomia were determined.
The incidences of preeclampsia, cesarean section, SGA, macrosomia, and postpartum hemorrhage in the paternal obesity group were significantly higher than the normal BMI group. With the increase of paternal BMI, fetal ultrasound measurement parameter, neonatal and placental weight showed an increasing trend (trend P < 0.05). However, these differences disappeared in the obese group. The test for interaction showed the effect of paternal obesity on SGA and macrosomia was significantly affected by maternal obesity. We also found paternal obesity was an independent predictor of both SGA and macrosomia. Based on the above results, we plotted the Nomograms for clinical prediction.
Paternal obesity can affect fetal growth parameters and placental development, which has an adverse impact on pregnancy outcomes. Optimizing the paternal BMI will help improve the health of the next generation.
评估父体肥胖与胎儿发育和妊娠并发症的关联。
本前瞻性队列临床试验分析了 7683 名单胎妊娠女性的数据。所有研究对象均根据父体 BMI 依次分为四组。我们通过单因素逻辑回归和独立 t 检验比较了不同父体 BMI 组之间胎儿生长和妊娠并发症的差异。最后，确定了 SGA 和巨大儿的独立预测因素。
父体肥胖组子痫前期、剖宫产、SGA、巨大儿和产后出血的发生率明显高于正常 BMI 组。随着父体 BMI 的增加，胎儿超声测量参数、新生儿和胎盘重量呈上升趋势（趋势 P < 0.05）。然而，在肥胖组这些差异消失了。交互作用检验表明，父体肥胖对 SGA 和巨大儿的影响显著受母体肥胖的影响。我们还发现父体肥胖是 SGA 和巨大儿的独立预测因素。基于上述结果，我们绘制了临床预测的 Nomogram。
父体肥胖会影响胎儿生长参数和胎盘发育，对妊娠结局产生不利影响。优化父体 BMI 将有助于改善下一代的健康。
