MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.
Bristol Dental School, University of Bristol, Bristol, UK.
Diabetologia. 2019 Oct;62(10):1802-1810. doi: 10.1007/s00125-019-4919-9. Epub 2019 Aug 27.
The aetiologies of obesity and type 2 diabetes are incredibly complex, but the potential role of paternal influences remains relatively understudied. A better understanding of paternal influences on offspring risk of obesity and type 2 diabetes could have profound implications for public health, clinical practice and society. In this review, we outline potential biological and social mechanisms through which fathers might exert an impact on the health of their offspring. We also present a systematically compiled overview of the current evidence linking paternal factors to offspring development of obesity and type 2 diabetes throughout the life course. Although evidence is accumulating to support paternal associations with offspring outcomes, more high-quality research is needed to overcome specific methodological challenges and provide stronger causal evidence.
肥胖和 2 型糖尿病的病因极其复杂，但父系影响的潜在作用仍相对研究不足。更好地了解父系对后代肥胖和 2 型糖尿病风险的影响，可能对公共卫生、临床实践和社会产生深远影响。在这篇综述中，我们概述了父亲可能通过哪些潜在的生物学和社会机制对后代的健康产生影响。我们还系统地综述了目前的证据，这些证据将父亲的因素与后代在整个生命周期中肥胖和 2 型糖尿病的发展联系起来。尽管有越来越多的证据支持与后代结局的父亲关联，但需要更多高质量的研究来克服特定的方法学挑战，并提供更强的因果证据。
