Win Shwe Sin, Klungsøyr Kari, Egeland Grace M, Sulo Gerhard
Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway.
Department of Health Promotion, Norwegian Institute of Public Health, Bergen, Norway.
PLoS One. 2025 Jan 8;20(1):e0313821. doi: 10.1371/journal.pone.0313821. eCollection 2025.
Studies have reported that pregnancies conceived by fathers with modifiable cardiovascular risk factors are at higher risk of ending in losses compared to those without such risk factors. Our objective was to examine the association between paternal family history a non-modifiable risk factor of premature atherosclerotic disease and perinatal death.
This is a population-based cohort study. Information on fathers, aged 18-50 years who participated in three population-based health surveys conducted in Norway during 1974-2003 was linked to their singleton births registered in the Medical Birth Registry of Norway. We used multilevel mixed effect logistic regression analyses with random intercepts by father's identification number. The birth was the observation unit in all analyses.
A total of 220,386 fathers who had 512,111 births with information on family history of CHD (12.3% with positive family history) and 203,257 births with information on family history of stroke (9.2% with positive family history) were analysed. There were 782 (1.3%) and 195 (1%) perinatal deaths in births to fathers with family history of CHD and stroke while 5,922 (1.3%) and 1,858 (1%) in those without family histories. We found no association between family history of CHD and stillbirth (OR 1.01, 95% CI 0.92; 1.12), neonatal death (OR 0.98, 95%CI 0.86, 1.11) or perinatal death (OR 1.00, 95% CI 0.92, 1.08). Similarly, we found no associations between family history of stroke and stillbirth (OR 1.00, 95% CI 0.82, 1.21), neonatal death (OR 1.09, 95%CI 0.84, 1.41) or perinatal death (OR 1.02, 95% CI 0.88, 1.20).
Socioeconomic background of fathers was captured using imperfect proxy. Potential misclassification of family history and selection bias should be considered.
Results of this large, cohort study including half-a million births, do not indicate an association between paternal family history of premature atherosclerotic disease and perinatal death.
研究报告称，与没有可改变心血管危险因素的父亲所孕育的妊娠相比，有此类危险因素的父亲所孕育的妊娠以流产告终的风险更高。我们的目的是研究父亲家族性早发性动脉粥样硬化疾病（一种不可改变的危险因素）与围产期死亡之间的关联。
这是一项基于人群的队列研究。1974年至2003年期间在挪威参加了三次基于人群的健康调查的18至50岁父亲的信息，与他们在挪威医疗出生登记处登记的单胎出生信息相关联。我们使用多级混合效应逻辑回归分析，并按父亲的识别号码进行随机截距。在所有分析中，出生是观察单位。
总共分析了220,386名父亲，他们有512,111次出生记录有冠心病家族史信息（12.3%有阳性家族史），203,257次出生记录有中风家族史信息（9.2%有阳性家族史）。有冠心病家族史和中风家族史的父亲所生孩子的围产期死亡分别为782例（1.3%）和195例（1%），而无家族史的分别为5,922例（1.3%）和1,858例（1%）。我们发现冠心病家族史与死产（比值比1.01，95%置信区间0.92；1.12）、新生儿死亡（比值比0.98，95%置信区间0.86，1.11）或围产期死亡（比值比1.00，95%置信区间0.92，1.08）之间无关联。同样，我们发现中风家族史与死产（比值比1.00，95%置信区间0.82，1.21）、新生儿死亡（比值比1.09，95%置信区间0.84，1.41）或围产期死亡（比值比1.02，95%置信区间0.88，1.20）之间无关联。
使用不完美的代理指标获取父亲的社会经济背景。应考虑家族史的潜在错误分类和选择偏倚。
这项包括50万例出生的大型队列研究结果表明，父亲早发性动脉粥样硬化疾病家族史与围产期死亡之间无关联。
