Shi Min, Li Xiao-Feng, Zhang Ting-Bao, Tang Qing-Wen, Peng Mian, Zhao Wen-Yuan
Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Front Neurosci. 2022 Mar 10;16:825859. doi: 10.3389/fnins.2022.825859. eCollection 2022.
The neutrophil-to-lymphocyte ratio (NLR) plays an important role in the progression of intracerebral hemorrhage (ICH). An increasing number of studies have reported that a high NLR is correlated with poor clinical outcomes among patients with ICH. Here, we conducted a systematic review and meta-analysis to evaluate the prognostic value of NLR in the setting of ICH. We performed a comprehensive search of electronic literature databases to identify all relevant studies evaluating the prognostic role of NLR in patients with ICH. Two researchers independently screened the studies and extracted relevant data. We extracted, pooled, and weighted odds ratio (OR) and 95% confidence interval (CI) values using a generic inverse-variance method, and then evaluated the heterogeneity among studies using test and statistic. Finally, we selected a total of 26 studies including 7,317 patients for the current study. Overall, our results indicated that a high NLR was significantly associated with a poor outcome (OR, 1.32; 95% CI, 1.19-1.46; < 0.00001), mortality (OR, 1.05; 95% CI, 1.01-1.09; = 0.02), and neurological deterioration (OR, 1.65; 95% CI, 1.08-2.52; = 0.02). We did not observe a significant association between NLR and hematoma expansion (OR, 1.04; 95% CI, 0.99-1.08; = 0.09). Our study indicated that a high NLR is significantly associated with poor clinical outcomes in patients with ICH. As NLR is a simple and easily available biomarker, future studies should focus on exploring its application in the prognostic evaluation of patients with ICH.
中性粒细胞与淋巴细胞比值（NLR）在脑出血（ICH）进展中起重要作用。越来越多的研究报道，高NLR与ICH患者不良临床结局相关。在此，我们进行了一项系统评价和荟萃分析，以评估NLR在ICH中的预后价值。我们全面检索电子文献数据库，以识别所有评估NLR在ICH患者中预后作用的相关研究。两名研究人员独立筛选研究并提取相关数据。我们使用通用逆方差法提取、合并并加权比值比（OR）和95%置信区间（CI）值，然后使用检验和统计量评估研究间的异质性。最后，我们共纳入26项研究，包括7317例患者进行本研究。总体而言，我们的结果表明，高NLR与不良结局（OR，1.32；95%CI，1.19 - 1.46；<0.00001）、死亡率（OR，1.05；95%CI，1.01 - 1.09；=0.02）及神经功能恶化（OR，1.65；95%CI，1.08 - 2.52；=0.02）显著相关。我们未观察到NLR与血肿扩大之间存在显著关联（OR，1.04；95%CI，0.99 - 1.08；=0.09）。我们的研究表明，高NLR与ICH患者不良临床结局显著相关。由于NLR是一种简单且易于获取的生物标志物，未来研究应聚焦于探索其在ICH患者预后评估中的应用。
