Zhang Jing, Cai Linrui, Song Yanlin, Shan Baoyin, He Min, Ren Qingqing, Chen Chaoyue, Liu Zhiyong, Zeng Yunhui, Xu Jianguo
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, PR China.
National Drug Clinical Trial Institute of West China Second University Hospital, Sichuan University, Chengdu 610041, PR China.
Oncotarget. 2017 Sep 8;8(44):77752-77760. doi: 10.18632/oncotarget.20776. eCollection 2017 Sep 29.
The aim of this study was to evaluate the prognostic role of neutrophil lymphocyte ratio (NLR) in patients with spontaneous intracerebral hemorrhage (ICH). PubMed, EMBASE, Web of Knowledge, Cochrane Library and China National Knowledge Infrastructure were searched for potentially relevant literature. The study and patient characteristics were extracted. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled to estimate the prognostic role of NLR in patients with ICH. Poor functional outcome was defined as modified Rankin Scale≥3. Four studies with 1,720 patients were included. The pooled OR of higher NLR for poor functional outcome at 3 months was 2.74 (95% CI, 1.33-5.65). The pooled OR of higher NLR for death at 3 months was 1.58 (95% CI, 0.44-5.68). Subgroup analysis and sensitivity analysis were also performed. Publication bias was not present. In conclusion, for patients with ICH, higher NLR was associated with poorer functional outcome at 3 months, while higher NLR was not associated with higher risk of death at 3 months.
本研究旨在评估中性粒细胞淋巴细胞比值（NLR）在自发性脑出血（ICH）患者中的预后作用。检索了PubMed、EMBASE、Web of Knowledge、Cochrane图书馆和中国知网中潜在相关文献。提取了研究和患者特征。汇总具有95%置信区间（CI）的比值比（OR），以评估NLR在ICH患者中的预后作用。功能结局不良定义为改良Rankin量表评分≥3分。纳入了四项研究，共1720例患者。3个月时NLR升高与功能结局不良的汇总OR为2.74（95%CI，1.33 - 5.65）。3个月时NLR升高与死亡的汇总OR为1.58（95%CI，0.44 - 5.68）。还进行了亚组分析和敏感性分析。不存在发表偏倚。总之，对于ICH患者，较高的NLR与3个月时较差的功能结局相关，而较高的NLR与3个月时较高的死亡风险无关。
