Habib Z
Obstet Gynecol Surv. 1978 Jul;33(7):441-7. doi: 10.1097/00006254-197807000-00001.
Modern neonatal care and advanced plastic surgical correction have led to the survival of most newborns with oral clefts. These children are likely to reproduce. A slight increase in the incidence of oral clefts may be expected in the future. The genetics of cleft lip and cleft palate is reviewed. The inheritance is usually multifactorial. With normal parents the risk of having a first affected child with cleft lip is about one per thousand, the risk of having a second affected child 4 per cent and the risk of having a third affected child 10 per cent. If a parent has already a cleft lip, the risk of having a first affected child now is 4 per cent, while the risk of having a second affected child is 10 per cent. The methodology of genetic counseling is given.
现代新生儿护理和先进的整形手术矫正使得大多数患有唇腭裂的新生儿得以存活。这些孩子有可能生育后代。预计未来唇腭裂的发病率会略有上升。本文综述了唇腭裂的遗传学。其遗传通常是多因素的。父母正常时，生育第一个患唇裂孩子的风险约为千分之一，生育第二个患唇裂孩子的风险为4%，生育第三个患唇裂孩子的风险为10%。如果父母一方已经患有唇裂，那么生育第一个患唇裂孩子的风险为4%，生育第二个患唇裂孩子的风险为10%。文中给出了遗传咨询的方法。
