血清和尿液中性粒细胞明胶酶相关脂质运载蛋白水平作为尿路结石所致肾积水患者肾功能的早期标志物
Serum and Urinary Neutrophil Gelatinase-Associated Lipocalin Levels as Early Markers of the Renal Function in Patients With Urinary Stone-Induced Hydronephrosis.
作者信息
Xie Tiancheng, Zhou Hongmin, Gao Yuchen, Xu Xiao, Yao Xudong, He Xulin, Xu Yunfei
机构信息
Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
出版信息
Front Surg. 2022 Mar 14;9:843098. doi: 10.3389/fsurg.2022.843098. eCollection 2022.
INTRODUCTION
Urinary stones cause hydronephrosis, which leads to kidney function impairment. The serum creatinine level is frequently used as a marker of kidney function. However, in some patients with hydronephrosis, it does not reflect the kidney function changes in the early stages of kidney stone disease. Neutrophil gelatinase-associated lipocalin (NGAL) is a novel indicator of the kidney function. Previous NGAL-related research has focused on its role in acute kidney injury. This study aimed to determine the usefulness of NGAL as an early marker of the kidney function in patients with urinary stones and hydronephrosis.
METHODS
Eighty-five patients with urinary stones who were admitted to the Shanghai Tenth People's Hospital (USP group) and 65 healthy volunteers (NC group) were recruited. Blood and urine samples collected from the study participants were evaluated using an enzyme-linked immunosorbent assay to determine the NGAL concentration. Data on the height, weight, age, medical history, and blood and urine findings were collected. Computed tomography data were collected from the USP group.
RESULTS
Compared to in the NC group, NGAL levels were significantly elevated in the USP group ( < 0.001). However, no significant differences in the NGAL levels were observed among the USP group members with different degrees of hydronephrosis. Furthermore, no significant between-group differences in the creatinine level or the estimated glomerular filtration rate were observed. The areas under the receiver operating characteristic curves for the serum and urinary NGAL levels with hydronephrosis were 92.03 and 99.54%, respectively. The areas under the receiver operating characteristic curves for the serum and urinary NGAL levels with kidney stones were 85.05 and 91.89%, respectively.
CONCLUSION
NGAL is a sensitive indicator of hydronephrosis secondary to urinary stones.
引言
尿路结石会导致肾积水，进而引起肾功能损害。血清肌酐水平常被用作肾功能的标志物。然而，在一些肾积水患者中，它并不能反映肾结石疾病早期的肾功能变化。中性粒细胞明胶酶相关脂质运载蛋白（NGAL）是一种新的肾功能指标。以往与NGAL相关的研究主要集中在其在急性肾损伤中的作用。本研究旨在确定NGAL作为尿路结石和肾积水患者肾功能早期标志物的实用性。
方法
招募了85例入住上海第十人民医院的尿路结石患者（USP组）和65名健康志愿者（NC组）。使用酶联免疫吸附测定法对研究参与者采集的血液和尿液样本进行评估，以确定NGAL浓度。收集有关身高、体重、年龄、病史以及血液和尿液检查结果的数据。从USP组收集计算机断层扫描数据。
结果
与NC组相比，USP组的NGAL水平显著升高（<0.001）。然而，在不同程度肾积水的USP组成员中，未观察到NGAL水平有显著差异。此外，在肌酐水平或估计肾小球滤过率方面未观察到组间显著差异。血清和尿液NGAL水平对肾积水的受试者工作特征曲线下面积分别为92.03%和99.54%。血清和尿液NGAL水平对肾结石的受试者工作特征曲线下面积分别为85.05%和91.89%。
结论
NGAL是尿路结石继发肾积水的敏感指标。
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