Thibert M R, Carroll S E
Can J Surg. 1986 Nov;29(6):402-4.
Because platelet aggregation is the critical step in vascular thrombosis, this study investigated the possibility that acetylsalicylic acid given orally would improve patency of anastomoses in small arteries. Under clean conditions, in male Sprague-Dawley rats, the superficial femoral arteries were divided and reanastomosed using the sleeve technique with 10-0 nylon suture. Fifty-one rats received a full laboratory diet and acetylsalicylic acid in their drinking water (1.08 mg/ml), before and after operation. A control group of 54 rats was matched for weight, water intake and duration of vessel occlusion. Vessel patency was assessed on postoperative day 7, at sacrifice, by dye angiography. In the experimental group 7 (13.7%) anastomoses became occluded, compared with 20 (37.0%) in the control group (chi 2 = 5.99, df = 1, p less than 0.025). Serum thromboxane B2 levels in five rats given acetylsalicylic acid orally (33.1 +/- 6.1 ng/ml) were significantly (p less than 0.001) lower than in five control rats (86.6 +/- 49.1 ng/ml). The authors concluded that acetylsalicylic acid administered in the drinking water to Sprague-Dawley rats improved the patency rate of femoral artery anastomoses probably because of a reduction in platelet aggregation. Orally administered acetylsalicylic acid may be of clinical benefit to patients who undergo small-vessel anastomoses.
由于血小板聚集是血管血栓形成的关键步骤，本研究调查了口服乙酰水杨酸能否改善小动脉吻合口通畅性的可能性。在清洁条件下，对雄性Sprague-Dawley大鼠，采用袖套技术用10-0尼龙缝线将股浅动脉切断并重新吻合。51只大鼠在手术前后饮用含乙酰水杨酸（1.08 mg/ml）的全实验室饲料和饮水。将54只大鼠作为对照组，使其在体重、饮水量和血管闭塞持续时间方面相匹配。在术后第7天处死动物时，通过染料血管造影评估血管通畅情况。实验组有7处（13.7%）吻合口闭塞，而对照组有20处（37.0%）吻合口闭塞（χ² = 5.99，自由度 = 1，p < 0.025）。口服乙酰水杨酸的5只大鼠血清血栓素B2水平（33.1 ± 6.1 ng/ml）显著低于5只对照大鼠（86.6 ± 49.1 ng/ml）（p < 0.001）。作者得出结论，给Sprague-Dawley大鼠饮用含乙酰水杨酸的水可提高股动脉吻合口的通畅率，这可能是由于血小板聚集减少所致。口服乙酰水杨酸可能对接受小血管吻合术的患者具有临床益处。
