Yuk Jin-Sung, Kim Myounghwan
Department of Obstetrics and Gynecology, School of Medicine, Sanggye Paik Hospital, Inje University, Seoul, South Korea.
Front Med (Lausanne). 2022 Mar 10;9:849660. doi: 10.3389/fmed.2022.849660. eCollection 2022.
Uterine leiomyomas are the most commonly observed pathologies, with an estimated prevalence of 4. 5-68.6%. We aimed to calculate myomectomy-related mortality and venous thromboembolism incidence rates in the Republic of Korea.
The data of patients who underwent myomectomy (2009-2018) were obtained from the Health Insurance Review and Assessment Service-National Inpatient Sample. The mortality rate after myomectomy was calculated using the leiomyoma diagnostic codes and myomectomy procedure codes. The incidence rates of venous thromboembolism, deep vein thrombosis, and pulmonary embolism were calculated using their diagnostic codes, with concomitant use of an antithrombotic agent during the same period or within 90 days after myomectomy.
The data of 23,549 women aged 15-55 years who underwent myomectomy were extracted. The myomectomy rate was 14.6 ± 0.1 per 10,000 patients. The average age was 39.39 ± 0.04 years. One patient who underwent myomectomy died; this patient did not have concomitant venous thromboembolism. The post-myomectomy mortality rate was 1.3 ± 0.8 per 10,000 patients. The incidence rates of venous thromboembolism, deep vein thrombosis, and pulmonary embolism after myomectomy were 5.7 ± 1.6 per 10,000 patients, 4.4 ± 1.4 per 10,000 patients, and 2.5 ± 1 per 10,000 patients, respectively. The conversion rate to hysterectomy was 2.9 ± 1.1 per 10,000 patients.
The current mortality rate after myomectomy (0.013%) is substantially lower than that described in previous studies at the turn of the 20th century. The incidence of venous thromboembolism is also considerably lower than that in the general population worldwide.
子宫平滑肌瘤是最常见的病理情况，估计患病率为4.5%-68.6%。我们旨在计算韩国子宫肌瘤切除术相关的死亡率和静脉血栓栓塞发生率。
从健康保险审查和评估服务机构-全国住院患者样本中获取2009年至2018年接受子宫肌瘤切除术患者的数据。使用平滑肌瘤诊断代码和子宫肌瘤切除手术代码计算子宫肌瘤切除术后的死亡率。使用静脉血栓栓塞、深静脉血栓形成和肺栓塞的诊断代码，并结合同期或子宫肌瘤切除术后90天内使用抗血栓药物的情况，计算其发生率。
提取了23549名年龄在15至55岁之间接受子宫肌瘤切除术的女性的数据。子宫肌瘤切除率为每10000名患者14.6±0.1例。平均年龄为39.39±0.04岁。一名接受子宫肌瘤切除术的患者死亡；该患者未伴有静脉血栓栓塞。子宫肌瘤切除术后的死亡率为每10000名患者1.3±0.8例。子宫肌瘤切除术后静脉血栓栓塞、深静脉血栓形成和肺栓塞的发生率分别为每10000名患者5.7±1.6例、4.4±1.4例和2.5±1例。子宫切除术的转化率为每10000名患者2.9±1.1例。
目前子宫肌瘤切除术后的死亡率（0.013%）远低于20世纪之交以前的研究报道。静脉血栓栓塞的发生率也远低于全球普通人群。
