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中国妊娠相关静脉血栓栓塞症的医院差异及相关组织因素

Hospital Variation and Associated Organizational Factors of Pregnancy-Related Venous Thromboembolism in China.

作者信息

Zhou Qiongjie, Zhao Zhekun, Xu Jinghui, Xiong Yu, Li Xiaotian

机构信息

Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, China.

出版信息

Clin Appl Thromb Hemost. 2022 Jan-Dec;28:10760296221076148. doi: 10.1177/10760296221076148.

Abstract

OBJECTIVE

Identifying organizational factors affecting venous thromboembolism (VTE) incidence and variations between hospitals.

METHODS

From a 2019 survey of VTE and live births in 113 hospitals, organizational factors: (hospital type, characteristics, live birth number), resource availability: (D-dimer, B-scan ultrasonography of lower extremity veins, computed tomographic pulmonary angiography [CTPA], and competency: [risk assessment, use of anticoagulants and patient education], data were collected and the associations, weighted by live birth number, analyzed.

RESULTS

Of 113 hospitals in China, 770,828 live births and 526 cases of VTE (68.2 per 100,000 live births) were reported. Nine hospitals lacked B-scan ultrasonography of lower extremity veins and 22 lacked CTPA. Prevalence rates of VTE rates were higher in general hospitals (Odds ratio [OR] = 4.251, 95% CI: 3.373-5.357), hospitals with live births < 10,000 (OR = 1.650-2.193), and hospitals without B-scan ultrasonography (OR = 1.661, 95% CI: 1.096-2.518). Hospitals implementing patient education, had a lower risk of VTE (OR = 0.296-0.374), and VTE rate decreased with the annual increase in live births.

CONCLUSIONS

Improved hospital resource availability and competency, especially patient education, is vital for reducing VTE-related maternal mortality and morbidity risk.

摘要

目的

确定影响静脉血栓栓塞症(VTE)发病率及医院间差异的组织因素。

方法

通过对113家医院2019年VTE和活产情况的调查,收集组织因素(医院类型、特征、活产数)、资源可用性(D-二聚体、下肢静脉B超、计算机断层扫描肺动脉造影[CTPA])和能力(风险评估、抗凝剂使用及患者教育)的数据,并以活产数为权重分析其关联性。

结果

中国113家医院共报告770,828例活产和526例VTE(每10万例活产中68.2例)。9家医院缺乏下肢静脉B超,22家缺乏CTPA。综合医院(优势比[OR]=4.251,95%可信区间:3.373 - 5.357)、活产数<10,000的医院(OR=1.650 - 2.193)以及没有下肢静脉B超的医院(OR=1.661,95%可信区间:1.096 - 2.518)的VTE患病率较高。实施患者教育的医院VTE风险较低(OR=0.296 - 0.374),且VTE发病率随活产数逐年增加而降低。

结论

提高医院资源可用性和能力,尤其是患者教育,对于降低与VTE相关的孕产妇死亡率和发病率风险至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/917f/8980411/819d15410502/10.1177_10760296221076148-fig1.jpg

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