弱视的药理学

The pharmacology of amblyopia.

作者信息

Duffy F H, Burchfiel J L, Snodgrass S R

出版信息

Ophthalmology. 1978 May;85(5):489-95. doi: 10.1016/s0161-6420(78)35648-7.

Abstract

Physiologic and anatomic evidence has suggested an anatomic disconnection between the deprived eye and visual cortical neurons in cats made amblyopic by monocular deprivation. Clinical and visual-evoked response data suggest, however, that inhibition may play a major role in amblyopia. Accordingly, we intravenously administered anti-inhibitory compounds (bicuculline, ammonium ion, naloxone) to amblyopic cats and demonstrated a substantial restoration of binocular input to the visual cortex. Such pharmacologic reversal suggests that amblyopia is not an anatomically fixed lesion.

摘要

生理学和解剖学证据表明，在因单眼剥夺而致弱视的猫中，被剥夺眼与视皮层神经元之间存在解剖学上的联系中断。然而，临床和视觉诱发电位数据表明，抑制作用可能在弱视中起主要作用。因此，我们给弱视猫静脉注射抗抑制化合物（荷包牡丹碱、铵离子、纳洛酮），并证明视皮层的双眼输入得到了实质性恢复。这种药理学上的逆转表明，弱视不是一种解剖学上固定不变的病变。