皮质内抑制在剥夺性弱视中的作用：微量离子电泳应用荷包牡丹碱后的逆转

Role of intracortical inhibition in deprivation amblyopia: reversal by microiontophoretic bicuculline.

作者信息

Burchfiel J L, Duffy F H

出版信息

Brain Res. 1981 Feb 16;206(2):479-84. doi: 10.1016/0006-8993(81)90551-5.

Abstract

The GABA antagonist, bicuculline, was microiontophoretically applied to 31 cells in the visual cortices of 4 cats monocularly deprived of vision from birth to time of study at age 5 months. Bicuculline restored input from the deprived eye to 42% of cells studied. Elevation of background firing rates by glutamate failed to restore deprived eye input. We suggest that intracortical inhibition plays an important role in maintaining the physiological abnormalities produced in visual cortex by monocular deprivation.

摘要

γ-氨基丁酸（GABA）拮抗剂荷包牡丹碱通过微量离子电泳法作用于4只出生时即单眼剥夺视觉的猫的视皮层中的31个细胞，这些猫在5个月大时接受研究。荷包牡丹碱使来自剥夺眼的输入恢复到所研究细胞的42%。谷氨酸提高背景放电率未能恢复剥夺眼的输入。我们认为，皮质内抑制在维持单眼剥夺所致视皮层生理异常方面起重要作用。