Department of Psychology, Syracuse University, 430 Huntington Hall, 13244, Syracuse, NY, USA.
Behavioral Medicine Program, Massachusetts General Hospital, Boston, USA.
AIDS Behav. 2022 Oct;26(10):3153-3163. doi: 10.1007/s10461-022-03657-x. Epub 2022 Apr 1.
Alcohol consumption is one of the strongest predictors of suboptimal adherence to antiretroviral therapy (ART), however, there is little research that has investigated both within- and between-person associations of alcohol consumption and ART adherence at the event-level. In this secondary data-analysis, (N = 22) HIV-positive MSM prospectively reported daily alcohol consumption and ART adherence for 42-days. Multilevel models demonstrated (1) days in which participants reported consuming any alcohol was associated with 2.48 increased odds of ART non-adherence, compared to days in which participants reported no alcohol consumption, and (2) there was a non-significant trend indicating days in which participants reported consuming greater than their own average levels of alcohol was associated with increased odds of ART non-adherence. Findings highlight the importance of combining intervention efforts that address alcohol consumption and suboptimal ART adherence, and indicate a need for future research to investigate the mechanisms by which alcohol influences ART adherence.
饮酒是导致抗逆转录病毒疗法（ART）依从性不佳的最强预测因素之一，但很少有研究调查过饮酒与 ART 依从性在个体内和个体间的关联。在这项二次数据分析中，（N=22）HIV 阳性男男性行为者前瞻性地报告了 42 天的每日饮酒量和 ART 依从性。多水平模型表明：（1）与报告未饮酒的天数相比，报告饮酒的天数与 ART 不依从的几率增加 2.48 倍；（2）报告饮酒量超过自身平均水平的天数与 ART 不依从的几率增加呈非显著趋势。研究结果强调了将解决饮酒和 ART 依从性不佳问题的干预措施结合起来的重要性，并表明需要进一步研究酒精影响 ART 依从性的机制。
