Chen Junyi, Hooley Richard J, Zhong Wenwan
Bioconjug Chem. 2022 Dec 21;33(12):2245-2253. doi: 10.1021/acs.bioconjchem.2c00096. Epub 2022 Apr 1.
Synthetic receptors are powerful tools for molecular recognition. They can bind to guests with high selectivity and affinity, and their structures are tunable and diversified. These features, plus the relatively low cost and high simplicity in synthesis and modification, support the feasibility of array-based molecular analysis with synthetic receptors for improved selectivity in the recognition of a wide range of targets. More attractively, host-guest interaction is reversible and guest displacement allows biocompatible and gentle release of the host-bound molecules, simplifying the stimulation designs needed to control analyte sensing, enrichment, and transportation. Here, we highlight a few recent advancements in using synthetic receptors for molecular analysis and manipulation, with the focus on macrocyclic receptors and their applications in displacement sensing, separation, imaging, and drug transport.
合成受体是用于分子识别的强大工具。它们能够以高选择性和亲和力结合客体，并且其结构具有可调节性和多样性。这些特性，再加上合成和修饰过程中相对较低的成本以及高度的简便性，支持了利用合成受体进行基于阵列的分子分析以提高对广泛目标识别选择性的可行性。更具吸引力的是，主客体相互作用是可逆的，客体置换允许生物相容性地温和释放与主体结合的分子，从而简化了控制分析物传感、富集和运输所需的刺激设计。在此，我们重点介绍了使用合成受体进行分子分析和操作的一些最新进展，重点是大环受体及其在置换传感、分离、成像和药物运输中的应用。
