EB 病毒是多发性硬化症的驱动因素。
Epstein-Barr virus as a driver of multiple sclerosis.
机构信息
KG Jebsen Centre for Coeliac Disease Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway and Department of Immunology, Oslo University Hospital - Rikshospitalet, Oslo, Norway. Email:
出版信息
Sci Immunol. 2022 Apr;7(70):eabo7799. doi: 10.1126/sciimmunol.abo7799. Epub 2022 Apr 1.
PMID:35363541
Abstract
Accumulating evidence implicates Epstein-Barr virus (EBV) as an etiological factor in multiple sclerosis (MS). If EBV is a "driver" that causes antiviral immunity with associated autoimmune components rather than a "trigger" that unleashes self-perpetuating autoimmunity, then elimination of EBV would be a rational therapy for MS.
摘要
越来越多的证据表明，Epstein-Barr 病毒（EBV）是多发性硬化症（MS）的病因之一。如果 EBV 是一种“驱动因素”，它会引起抗病毒免疫和相关的自身免疫成分，而不是一种“触发因素”，那么消除 EBV 将是治疗 MS 的合理方法。
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